المؤلفون: Isabel Nogués, Andrzej Szczepaniak, Milosz Ruszkowski, Zbigniew Dauter, Sebastiana Angelaccio, Bartosz Sekula, Agnieszka Ruszkowska, Roberto Contestabile

المصدر: Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific reports (Nature Publishing Group) 9 (2019). doi:10.1038/s41598-019-56043-4
info:cnr-pdr/source/autori:Ruszkowski, Milosz; Sekula, Bartosz; Ruszkowska, Agnieszka; Contestabile, Roberto; Nogues, Isabel; Angelaccio, Sebastiana; Szczepaniak, Andrzej; Dauter, Zbigniew/titolo:Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models/doi:10.1038%2Fs41598-019-56043-4/rivista:Scientific reports (Nature Publishing Group)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:9

مصطلحات موضوعية: Arabidopsis, lcsh:Medicine, Pemetrexed, Crystallography, X-Ray, Isozyme, Thymidylate synthase, Article, Serine, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Transferases, x-ray crystallography, transferases, Dihydrofolate reductase, Medicago truncatula, Humans, lcsh:Science, serine hydroxymethyltransferases, 030304 developmental biology, X-ray crystallography, chemistry.chemical_classification, Glycine Hydroxymethyltransferase, 0303 health sciences, Multidisciplinary, biology, Chemistry, Arabidopsis Proteins, lcsh:R, 3. Good health, Isoenzymes, Enzyme, Methotrexate, Biochemistry, 030220 oncology & carcinogenesis, Antifolate, Cancer cell, biology.protein, lcsh:Q

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6874a4607c8eec9f06c6261ded1a11a6Test
http://link.springer.com/article/10.1038/s41598-019-56043-4Test

المؤلفون: Oliver M. Eder, Stewart D. Nuttall, Albert Ardevol, Thomas S. Peat, Janet Newman, Alessandro T. Caputo, Heleen Pothuis, Timothy E. Adams, Hana Bereznakova

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Expression systems, Science, Mutant, Protein design, Biologics, Crystallography, X-Ray, Biochemistry, Article, Cell Line, law.invention, 03 medical and health sciences, chemistry.chemical_compound, Acetyl Coenzyme A, Acetyltransferases, law, Catalytic Domain, Animals, Humans, X-ray crystallography, chemistry.chemical_classification, Multidisciplinary, 030102 biochemistry & molecular biology, Chemistry, Acetylation, Transfection, Recombinant Proteins, Streptomyces, Enzymes, HEK293 Cells, 030104 developmental biology, Enzyme, Gene Expression Regulation, Puromycin, Mutation, Recombinant DNA, Medicine, Target protein, Structural biology, Function (biology)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541e76503b7a59d18f3c3f108957c3cdTest
https://doaj.org/article/e3fd4beb677e4374affab46d03fe0260Test

المؤلفون: S. Tsimbalyuk, C. M. Donnelly, J. K. Forwood

المصدر: Scientific Reports
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)

مصطلحات موضوعية: Models, Molecular, Repetitive Sequences, Amino Acid, alpha Karyopherins, animal structures, Multidisciplinary, Protein transport, Science, Active Transport, Cell Nucleus, Crystallography, X-Ray, environment and public health, Article, Structure-Activity Relationship, Protein Domains, embryonic structures, Medicine, Humans, Protein Isoforms, X-ray crystallography, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::effa4b1d5077ce4304cfca6de84430a4Test
https://doi.org/10.1038/s41598-021-03729-3Test

المؤلفون: Thao N. T. Ho, Nikita Abraham, Richard J. Lewis

المصدر: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

مصطلحات موضوعية: Stereochemistry, Protein Conformation, Science, Venom, Receptors, Nicotinic, Crystallography, X-Ray, complex mixtures, Article, Acetylcholine binding, Isomerism, Ribbon, Membrane proteins, Animals, Humans, Amino Acid Sequence, α conotoxin, Acetylcholine receptor, X-ray crystallography, Multidisciplinary, Chemistry, Conus Snail, Loop (topology), Nicotinic agonist, nervous system, Globular cluster, Medicine, Structural biology, Peptides, Conotoxins

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ae480c92c500f21bd95d602a12eb25Test
http://europepmc.org/articles/PMC8578332Test

المؤلفون: Alexander V. Shkumatov, Sudeep Karki, Hyeonho Kim, Jaewon Ko, Sungwon Bae, Tommi Kajander

المساهمون: Institute of Biotechnology, University Management

المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports

مصطلحات موضوعية: Glycosylation, DNA Mutational Analysis, lcsh:Medicine, Protein tyrosine phosphatase, Crystallography, X-Ray, Ligands, MOLECULES, Mice, 0302 clinical medicine, Postsynaptic potential, Netrin, Scattering, Radiation, lcsh:Science, 0303 health sciences, TRANSMEMBRANE PROTEINS, Multidisciplinary, Membrane Glycoproteins, REFINEMENT, Chemistry, Cell adhesion molecule, Receptor-Like Protein Tyrosine Phosphatases, Class 2, Cell Differentiation, Adhesion, Ligand (biochemistry), Molecular biophysics, Transmembrane protein, FAMILY, Drosophila, Structural biology, LAR-RPTPS, Cell Adhesion Molecules, Neuronal, Mice, Transgenic, Nerve Tissue Proteins, INTERACTS, Leucine-rich repeat, Molecular neuroscience, Article, 03 medical and health sciences, Protein Domains, QUALITY, Animals, Humans, 030304 developmental biology, X-ray crystallography, lcsh:R, Proteins, Phosphoric Monoester Hydrolases, Fibronectins, HEK293 Cells, Synapses, Biophysics, 1182 Biochemistry, cell and molecular biology, lcsh:Q, Protein Multimerization, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a224ba35fb2bedee805d99b118a0eed3Test
http://link.springer.com/article/10.1038/s41598-020-68502-4Test

المؤلفون: Matthew T. G. Holden, Daniel Bawdon, Diana S. Cox, Anthony J. Wilkinson, Reyme Herman, Eleanor J. Dodson, Matthew Rose, Michelle Rudden, A. Gordon James, Gavin H. Thomas

المساهمون: University of St Andrews. School of Medicine, University of St Andrews. Biomedical Sciences Research Complex, University of St Andrews. Infection and Global Health Division, University of St Andrews. Infection Group

المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports

مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, Models, Molecular, Time Factors, Staphylococcus, lcsh:Medicine, Ligands, 01 natural sciences, lcsh:Science, Peptide sequence, Phylogeny, chemistry.chemical_classification, Human Body, Multidisciplinary, QR Microbiology, Carbon-Sulfur Lyases, Biochemistry, behavior and behavior mechanisms, medicine.symptom, Hydrophobic and Hydrophilic Interactions, psychological phenomena and processes, 010603 evolutionary biology, Microbiology, Article, 03 medical and health sciences, Bacterial Proteins, Phylogenetics, Body odour, parasitic diseases, medicine, Humans, Amino Acid Sequence, Cysteine, Sulfhydryl Compounds, Binding site, X-ray crystallography, Binding Sites, fungi, lcsh:R, DAS, Bayes Theorem, Lyase, QR, 030104 developmental biology, Enzyme, Structural biology, chemistry, Alcohols, Odorants, lcsh:Q, Function (biology)

وصف الملف: application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1935a09ac7ca0b3dcfdfedf6c67d391Test
http://link.springer.com/article/10.1038/s41598-020-68860-zTest

المؤلفون: Jianping Ding, Pengkai Sun, Tengfei Ma, Tuya Bai

المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports

مصطلحات موضوعية: Models, Molecular, Allosteric regulation, lcsh:Medicine, Crystallography, X-Ray, Article, Adenosine Triphosphate, Allosteric Regulation, Catalytic Domain, Humans, Chelation, lcsh:Science, X-ray crystallography, Enzyme Assays, chemistry.chemical_classification, Multidisciplinary, biology, Chemistry, lcsh:R, Active site, NAD, Heterotetramer, Enzyme assay, Isocitrate Dehydrogenase, Adenosine Diphosphate, Kinetics, Protein Subunits, Enzyme, Isocitrate dehydrogenase, Enzyme mechanisms, biology.protein, Biophysics, Biocatalysis, lcsh:Q, NAD+ kinase, Protein Multimerization, Allosteric Site

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61185b04843e31e8c908e582673b4d06Test
http://link.springer.com/article/10.1038/s41598-020-63425-6Test

المؤلفون: Ahmad W. Almawi, Javier Rodríguez González, Laurence Langlois-Lemay, Alba Guarné, Giuseppe Melacini, Damien D’Amours, Stephen Boulton

المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports

مصطلحات موضوعية: Saccharomyces cerevisiae Proteins, Cell division, Saccharomyces cerevisiae, Mitosis, lcsh:Medicine, Cell Cycle Proteins, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Article, Substrate Specificity, Domain (software engineering), 03 medical and health sciences, Proto-Oncogene Proteins, Animals, Humans, Amino Acid Sequence, Phosphorylation, Binding site, lcsh:Science, Zebrafish, X-ray crystallography, 030304 developmental biology, Anaphase, 0303 health sciences, Binding Sites, Multidisciplinary, biology, Chemistry, Kinase, 030302 biochemistry & molecular biology, lcsh:R, Cell Cycle Checkpoints, Zebrafish Proteins, biology.organism_classification, Protein Structure, Tertiary, 3. Good health, Cell biology, enzymes and coenzymes (carbohydrates), Mitotic exit, Mutagenesis, Site-Directed, lcsh:Q, biological phenomena, cell phenomena, and immunity, Solution-state NMR, Microtubule-Associated Proteins, Sequence Alignment, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2a8d23138d1a31e8802db3ac21179fTest
http://link.springer.com/article/10.1038/s41598-020-60344-4Test

المؤلفون: Beáta Oroszová, Benedetta Bertolotti, Kamil Parkan, Gita Paulíková, Michaela Wimmerová, Martina Kašáková, Jitka Moravcová, Josef Houser

المصدر: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Dendrimers, Erythrocytes, Stereochemistry, Glycobiology, lcsh:Medicine, 010402 general chemistry, Crystallography, X-Ray, Ligands, 01 natural sciences, Fucose, Article, 03 medical and health sciences, chemistry.chemical_compound, Bacterial Proteins, Dendrimer, Lectins, Humans, Binding site, Surface plasmon resonance, lcsh:Science, X-ray crystallography, Multidisciplinary, Binding Sites, biology, Hemagglutination, lcsh:R, Lectin, Isothermal titration calorimetry, Bacterial Infections, Surface Plasmon Resonance, HEXA, Recombinant Proteins, 0104 chemical sciences, Anti-Bacterial Agents, 030104 developmental biology, Monomer, chemistry, Host-Pathogen Interactions, biology.protein, lcsh:Q, Photorhabdus

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23fb2657066556739b09ac962ad0da63Test
http://link.springer.com/article/10.1038/s41598-019-51357-9Test

المؤلفون: M.A. Redhead, Patrick Collins, Tika R. Malla, Claire Strain-Damerell, Sean W. Robinson, Jan Thibaut, David I. Stuart, Anthony Tumber, Mark Swindells, C. David Owen, Philipp Schäfer, Chris J Radoux, Laura Vangeel, Frank von Delft, A.L. Hopkins, Mitchell V. Hull, Pieter Leyssen, Thomas Vercruysse, David J. Hallett, D. Fearon, Tu Trinh Nguyen, Martin A. Walsh, Alice Douangamath, Iva Navratilova Hopkins, Amelia H. Collette, Christopher J. Schofield, Lennart Brewitz, Petra Lukacik

المصدر: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

مصطلحات موضوعية: 0301 basic medicine, Coronavirus disease 2019 (COVID-19), Science, High-throughput screening, medicine.medical_treatment, Coronavirus Papain-Like Proteases, medicine.disease_cause, Antiviral Agents, Article, Cell Line, Viral Proteins, 03 medical and health sciences, SUBSTRATE, 0302 clinical medicine, RESPIRATORY SYNDROME CORONAVIRUS, INFLAMMATION, medicine, Humans, Coronavirus 3C Proteases, Serpins, X-ray crystallography, Coronavirus, Science & Technology, Multidisciplinary, Protease, SARS-CoV-2, M-PRO, Drug discovery, business.industry, Drug Repositioning, Publisher Correction, Replication cycle, Virology, COVID-19 Drug Treatment, Multidisciplinary Sciences, Drug repositioning, 030104 developmental biology, 030220 oncology & carcinogenesis, Enzyme mechanisms, Medicine, Science & Technology - Other Topics, INDUCED DIMERIZATION, INHIBITORS, business, Oligopeptides, Clinical evaluation

وصف الملف: Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98de1f2b95127b3bd5c89e404db2ce7Test
https://doi.org/10.1038/s41598-021-92416-4Test