SOG1 transcription factor promotes the onset of endoreduplication under salinity stress in Arabidopsis
| العنوان: | SOG1 transcription factor promotes the onset of endoreduplication under salinity stress in Arabidopsis |
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| المؤلفون: | Kalyan Mahapatra, Sujit Roy |
| المصدر: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-26 (2021) |
| بيانات النشر: | Nature Publishing Group UK, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0106 biological sciences, 0301 basic medicine, Programmed cell death, Cell cycle checkpoint, Plant molecular biology, DNA, Plant, DNA damage, Science, Arabidopsis, Plant cell biology, Cell Cycle Proteins, Ataxia Telangiectasia Mutated Proteins, Cyclin B, Protein Serine-Threonine Kinases, Sodium Chloride, 01 natural sciences, Salt Stress, Article, Polyploidy, 03 medical and health sciences, Gene Expression Regulation, Plant, Plant Cells, Plant development, Endoreduplication, Transcription factor, Cell Size, Multidisciplinary, biology, Arabidopsis Proteins, Salt Tolerance, Cell cycle, biology.organism_classification, Cyclin-Dependent Kinases, Cell biology, E2F Transcription Factors, G2 Phase Cell Cycle Checkpoints, Wee1, 030104 developmental biology, biology.protein, Medicine, 010606 plant biology & botany, Signal Transduction, Transcription Factors |
| الوصف: | As like in mammalian system, the DNA damage responsive cell cycle checkpoint functions play crucial role for maintenance of genome stability in plants through repairing of damages in DNA and induction of programmed cell death or endoreduplication by extensive regulation of progression of cell cycle. ATM and ATR (ATAXIA-TELANGIECTASIA-MUTATED and -RAD3-RELATED) function as sensor kinases and play key role in the transmission of DNA damage signals to the downstream components of cell cycle regulatory network. The plant-specific NAC domain family transcription factor SOG1 (SUPPRESSOR OF GAMMA RESPONSE 1) plays crucial role in transducing signals from both ATM and ATR in presence of double strand breaks (DSBs) in the genome and found to play crucial role in the regulation of key genes involved in cell cycle progression, DNA damage repair, endoreduplication and programmed cell death. Here we report that Arabidopsis exposed to high salinity shows generation of oxidative stress induced DSBs along with the concomitant induction of endoreduplication, displaying increased cell size and DNA ploidy level without any change in chromosome number. These responses were significantly prominent in SOG1 overexpression line than wild-type Arabidopsis, while sog1 mutant lines showed much compromised induction of endoreduplication under salinity stress. We have found that both ATM-SOG1 and ATR-SOG1 pathways are involved in the salinity mediated induction of endoreduplication. SOG1was found to promote G2-M phase arrest in Arabidopsis under salinity stress by downregulating the expression of the key cell cycle regulators, including CDKB1;1, CDKB2;1, and CYCB1;1, while upregulating the expression of WEE1 kinase, CCS52A and E2Fa, which act as important regulators for induction of endoreduplication. Our results suggest that Arabidopsis undergoes endoreduplicative cycle in response to salinity induced DSBs, showcasing an adaptive response in plants under salinity stress. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27dcfa00b075eacc19ea923a10ac1036Test http://europepmc.org/articles/PMC8172935Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....27dcfa00b075eacc19ea923a10ac1036 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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