التفاصيل البيبلوغرافية
| العنوان: |
Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth. |
| المؤلفون: |
Aki Yamashita, Kei Kawana, Kensuke Tomio, Ayumi Taguchi, Yosuke Isobe, Ryo Iwamoto, Koji Masuda, Hitomi Furuya, Takeshi Nagamatsu, Kazunori Nagasaka, Takahide Arimoto, Katsutoshi Oda, Osamu Wada-Hiraike, Takahiro Yamashita, Yuji Taketani, Kang, Jing X., Shiro Kozuma, Hiroyuki Arai, Makoto Arita, Yutaka Osuga |
| المصدر: |
Scientific Reports; 11/1/2013, p1-7, 7p |
| مصطلحات موضوعية: |
UNSATURATED fatty acids, CHILDBIRTH, EICOSAPENTAENOIC acid, OBSTETRICS, OMEGA-3 fatty acids, PREMATURE infants, PREMATURE labor |
| مستخلص: |
Omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) have anti-inflammatory effects. Preterm birth is an important problem in modern obstetrics and one of the main causes is an inflammation. We here showed that abundance of omega-3 fatty acids reduced the incidence of preterm birth induced by LPS with fat-1 mice, capable of converting omega-6 to omega-3 fatty acids. We also indicated that the gene expression of IL-6 and IL-1b in uteruses and the number of cervical infiltrating macrophages were reduced in fat-1 mice. The analyses of lipid metabolomics showed the high level of 18-hydroxyeicosapentaenoate in fat-1 mice, which was derived from EPA and was metabolized to anti-inflammatory product named resolvin E3 (RvE3). We finally showed that the administration of RvE3 to LPS-exposed pregnant wild type mice lowered the incidence of preterm birth. Our data suggest that RvE3 could be a potential new therapeutic for the prevention of preterm birth. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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