المؤلفون: Hiroyuki Motoyama, Norifumi Kawada, Kohei Kotani, Akihiro Tamori, Naoshi Odagiri, Hideki Fujii, Hoang Hai, Le Thi Thanh Thuy, Atsushi Hagihara, Minh Phuong Dong, Masaru Enomoto, Ritsuzo Kozuka, Etsushi Kawamura, Sawako Uchida-Kobayashi, Kanako Yoshida

المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Scientific Reports

مصطلحات موضوعية: Adult, Male, Carcinoma, Hepatocellular, Guanine, Time Factors, Science, Fluoroimmunoassay, Programmed Cell Death 1 Receptor, Antiviral Agents, Article, Hepatitis, Young Adult, Hepatitis B, Chronic, Predictive Value of Tests, Programmed cell death 1, medicine, Humans, Viral hepatitis, Aged, Multidisciplinary, biology, Nucleoside analogue, Hepatology, business.industry, Liver Neoplasms, Gastroenterology, Nucleosides, Middle Aged, medicine.disease, Treatment Outcome, Hepatocellular carcinoma, biology.protein, Cancer research, Medicine, Female, business, Biomarkers, medicine.drug

الوصف: Soluble immune checkpoint molecules are emerging novel mediators of immune regulation. However, it is unclear whether soluble immune checkpoint proteins affect the development of hepatocellular carcinoma (HCC) during nucleos(t)ide analogue (NA) treatment in patients with chronic hepatitis B virus infection. This study included 122 NA-naïve patients who received NA therapy. We assessed the associations of clinical factors, including soluble immune checkpoint proteins, with HCC development during NA treatment. The baseline serum concentrations of 16 soluble immune checkpoint proteins were measured using multiplexed fluorescent bead-based immunoassay. In total, 13 patients developed HCC during the follow-up period (median duration, 4.3 years). Of the 16 proteins, soluble inducible T-cell co-stimulator (≥ 164.71 pg/mL; p = 0.014), soluble programmed cell death-1 (sPD-1) (≤ 447.27 pg/mL; p = 0.031), soluble CD40 (≤ 493.68 pg/mL; p = 0.032), and soluble herpes virus entry mediator (≤ 2470.83 pg/mL; p = 0.038) were significantly associated with HCC development (log-rank test). In multivariate analysis, an sPD-1 level ≤ 447.27 pg/mL (p = 0.014; hazard ratio [HR], 4.537) and α-fetoprotein level ≥ 6.4 ng/mL (p = 0.040; HR, 5.524) were independently and significantly associated with HCC development. Pre-treatment sPD-1 is a novel predictive biomarker for HCC development during NA treatment.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4450d2a03fa611a7dd2cf18678b8b541Test
https://doaj.orgTest/article/68f24d6e6a1041038229292cc77e750c

المؤلفون: Chang-Chun Hsiao, Ting-Ya Wang, Mao-Chang Su, C Lee, Yong-Yong Lin, Meng-Chih Lin, Po-Yuan Hsu, Hsin-Ching Lin, Yung-Che Chen, Chia-Wei Liou, Chien-Hung Chin

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports

مصطلحات موضوعية: Male, Jumonji Domain-Containing Histone Demethylases, THP-1 Cells, medicine.medical_treatment, Excessive daytime sleepiness, Histone Deacetylase 1, Diseases, medicine.disease_cause, Cohort Studies, Histones, Medicine, Continuous positive airway pressure, Hypoxia, Promoter Regions, Genetic, Sleep Apnea, Obstructive, Multidisciplinary, biology, Continuous Positive Airway Pressure, Molecular medicine, Intermittent hypoxia, Acetylation, Middle Aged, Up-Regulation, Histone, C-Reactive Protein, NADPH Oxidase 1, Female, medicine.symptom, Adult, medicine.medical_specialty, Polysomnography, Science, Disorders of Excessive Somnolence, Peripheral blood mononuclear cell, Article, Sleep Apnea Syndromes, Medical research, Internal medicine, Humans, business.industry, Snoring, DNA Methylation, medicine.disease, HDAC1, Obstructive sleep apnea, Endocrinology, Case-Control Studies, biology.protein, Leukocytes, Mononuclear, business, Oxidative stress, Biomarkers

الوصف: The aim of this study is to determine the roles of global histone acetylation (Ac)/methylation (me), their modifying enzymes, and gene-specific histone enrichment in obstructive sleep apnea (OSA). Global histone modifications, and their modifying enzyme expressions were assessed in peripheral blood mononuclear cells from 56 patients with OSA and 16 matched subjects with primary snoring (PS). HIF-1α gene promoter-specific H3K36Ac enrichment was assessed in another cohort (28 OSA, 8 PS). Both global histone H3K23Ac and H3K36Ac expressions were decreased in OSA patients versus PS subjects. H3K23Ac expressions were further decreased in OSA patients with prevalent hypertension. HDAC1 expressions were higher in OSA patients, especially in those with excessive daytime sleepiness, and reduced after more than 6 months of continuous positive airway pressure treatment. H3K79me3 expression was increased in those with high C-reactive protein levels. Decreased KDM6B protein expressions were noted in those with a high hypoxic load, and associated with a higher risk for incident cardiovascular events or hypertension. HIF-1α gene promoter-specific H3K36Ac enrichment was decreased in OSA patients versus PS subjects. In vitro intermittent hypoxia with re-oxygenation stimuli resulted in HDAC1 over-expression and HIF-1α gene promoter-specific H3K36Ac under-expression, while HDAC1 inhibitor, SAHA, reversed oxidative stress through inhibiting NOX1. In conclusions, H3K23/H3K36 hypoacetylation is associated with the development of hypertension and disease severity in sleep-disordered breathing patients, probably through up-regulation of HDAC1, while H3K79 hypermethylation is associated with higher risk of cardiovascular diseases, probably through down-regulation of KDM6B.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5df41e5c83da43011517e8da1818415Test
https://doaj.orgTest/article/7aa0ddc6b9dc4f28aa0dbb61d068aad7

المؤلفون: Amisha Wallia, Samuel Dagogo-Jack, Ionut Bebu, Trevor J. Orchard, Barbara H. Braffett, Timothy J. Lyons, Alicia J. Jenkins, Arpita Basu, W. Timothy Garvey, Maria F. Lopes-Virella, John M. Lachin

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Science, 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, Article, 03 medical and health sciences, Endocrinology, 0302 clinical medicine, Internal medicine, Diabetes mellitus, Epidemiology, medicine, Humans, Hyperuricemia, cardiovascular diseases, Metabolic Syndrome, Type 1 diabetes, Multidisciplinary, business.industry, Middle Aged, medicine.disease, Uric Acid, Diabetes Mellitus, Type 1, Risk factors, Cardiovascular Diseases, Heart Disease Risk Factors, Cohort, Medicine, Female, Metabolic syndrome, business, Mace

الوصف: In type 2 diabetes, hyperuricemia is associated with cardiovascular disease (CVD) and the metabolic syndrome (MetS), but associations in type 1 diabetes (T1D) have not been well-defined. This study examined the relationships between serum urate (SU) concentrations, clinical and biochemical factors, and subsequent cardiovascular events in a well-characterized cohort of adults with T1D. In 973 participants with T1D in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC), associations were defined between SU, measured once in blood collected 1997–2000, and (a) concurrent MetS and (b) incident ‘any CVD’ and major adverse cardiovascular events (MACE) through 2013. SU was higher in men than women [mean (SD): 4.47 (0.99) vs. 3.39 (0.97) mg/dl, respectively, p Trial registration clinicaltrials.gov NCT00360815 and NCT00360893.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db6a0485c835ecd5ee1065359316a30Test
https://doaj.orgTest/article/f9fee4388877495b97606fb3d560869c

المؤلفون: Anthony C Keech, Yoon Hi Cho, Ryan J. Farr, Emma S. Scott, David N O'Neal, Anandwardhan A. Hardikar, Paul Z. Benitez-Aguirre, Mugdha V. Joglekar, Andrzej S. Januszewski, Luke M. Carroll, Alicia J. Jenkins, Maria E. Craig, Yik Wen Loh, Wilson K. M. Wong, Kim C. Donaghue

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports

مصطلحات موضوعية: Blood Glucose, Male, 0301 basic medicine, Diabetes duration, medicine.medical_treatment, Autoimmunity, 0302 clinical medicine, Insulin-Secreting Cells, Insulin Secretion, Medicine, Child, Aged, 80 and over, Multidisciplinary, C-Peptide, Age Factors, Middle Aged, Type 1 diabetes, Female, Adult, medicine.medical_specialty, Adolescent, Science, 030209 endocrinology & metabolism, Article, Young Adult, 03 medical and health sciences, Diabetes mellitus, Internal medicine, microRNA, Humans, Secretion, Circulating MicroRNA, Insulin secretion, Aged, Autoantibodies, Glycated Hemoglobin, business.industry, Insulin, medicine.disease, MicroRNAs, Diabetes Mellitus, Type 1, 030104 developmental biology, Endocrinology, Gene Expression Regulation, Genetic markers, Age of onset, business, Biomarkers

الوصف: The aim of this cross-sectional study was to compare plasma C-peptide presence and levels in people without diabetes (CON) and with Type 1 diabetes and relate C-peptide status to clinical factors. In a subset we evaluated 50 microRNAs (miRs) previously implicated in beta-cell death and associations with clinical status and C-peptide levels. Diabetes age of onset was stratified as adult (≥ 18 y.o) or childhood ( 20 years. Plasma C-peptide was measured by ultrasensitive ELISA. Plasma miRs were quantified using TaqMan probe-primer mix on an OpenArray platform. C-peptide was detectable in 55.3% of (n = 349) people with diabetes, including 64.1% of adults and 34.0% of youth with diabetes, p p p = 0.02, respectively]. In the childhood-onset group more people with longer diabetes duration (> 20 years) had detectable C-peptide (60%) than in those with shorter diabetes duration (39%, p for trend

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd5b712c5082c4c879f559920494d80Test
https://doaj.orgTest/article/b1ec56fdb12a4c0cb5cb32be78d2f006

المؤلفون: Jacqueline V. Schiesser, Thomas Loudovaris, Helen E. Thomas, Edouard G. Stanley, Andrew G. Elefanty

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Cell type, medicine.medical_treatment, Science, Cell, Integrin, Gene Expression, Biology, Immunofluorescence, Article, 03 medical and health sciences, 0302 clinical medicine, Insulin-Secreting Cells, medicine, Humans, Insulin, Receptors, Vitronectin, Beta (finance), geography, Multidisciplinary, geography.geographical_feature_category, medicine.diagnostic_test, Cluster of differentiation, Middle Aged, Islet, Gene expression profiling, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Type 1 diabetes, Diabetes Mellitus, Type 1, biology.protein, Medicine, Female, 030217 neurology & neurosurgery, Biomarkers

الوصف: The identification of cell surface markers specific to pancreatic beta cells is important for both the study of islet biology and for investigating the pathophysiology of diseases in which this cell type is lost or damaged. Following analysis of publicly available RNAseq data, we identified specific integrin subunits, integrin αv and integrin β5, that were expressed in beta cells. This finding was further elaborated using immunofluorescence analysis of histological sections derived from donor human pancreas. Despite the broad expression of specific integrin subunits, we found that expression of integrin αvβ5 heterodimers was restricted to beta cells and that this complex persisted in islet remnants of some type 1 diabetic individuals from which insulin expression had been lost. This study identifies αvβ5 heterodimers as a novel cell surface marker of human pancreatic beta cells, a finding that will aid in the identification and characterisation of this important cell type.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932b8419e0cfd10e677c6085465d5e16Test
https://doaj.orgTest/article/dcab1ff3fe334cd4b5b2b617cf023918

المؤلفون: Lidia Łysenko, Jaroslaw Janc, Ewa Woznica Niesobska, Patrycja Leśnik, Magdalena Mierzchala-Pasierb

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports

مصطلحات موضوعية: Adult, Male, Science, Diseases, Urinalysis, Article, Medical research, Humans, Hepatitis A Virus Cellular Receptor 1, Signs and symptoms, Kidney diseases, Multidisciplinary, Immunochemistry, Health care, Endocrine system and metabolic diseases, Middle Aged, Solutions, Risk factors, Nephrology, Thyroidectomy, Gelatin, Medicine, Female, Biomarkers

الوصف: Optimal fluid therapy significantly affects the maintenance of proper tissue perfusion and, consequently, kidney function. An adverse effect of colloids on kidney function is related to the incidence of postoperative kidney failure. The study aimed to assess the effect of a 3% gelatin solution on kidney function based on the urinary kidney injury molecule-1 (uKIM-1) level. This study used a parallel design and enrolled 64 adult patients with a mean age of 52.5 ± 13.1 years, all of whom underwent a thyroidectomy procedure under general anesthesia. Patients were randomly assigned to three comparison groups, each receiving a different dose of 3% gelatin solution during the thyroidectomy procedure. The patients from study groups A (n = 21) and B (n = 21) received a 3% gelatin solution at a dose of 30 ml/kg and 15 ml/kg body weight, respectively, during the first hour of the procedure. The patients from the control group C (n = 22) received an isotonic multi-electrolyte solution. Serum creatinine levels were determined, and urine samples were collected to determine levels of uKIM-1 before, 2 h, and 24 h after surgery. The patients’ demographic data, type and volume of fluid and hemodynamic status during the surgery were collected from relevant anesthesia protocols and were included in the study data. There were no statistically significant changes between groups in hemodynamic parameters such as systolic and diastolic blood pressure, heart rate, and oxygen saturation values. A statistically significant increase in uKIM-1 level was noted in patients receiving the 3% gelatin solution regardless of the dose. A statistically significant difference in uKIM-1 level was observed between groups A, B, and C measured 24 h after surgery, with the highest uKIM-1 level in group A. Measurement of uKIM-1 level could be an early and sensitive biomarker of kidney injury. Kidney toxicity of a 3% gelatin solution, evaluated based on the level of uKIM-1 in urine, correlates with transfused fluid volume. This study was retrospectively registered in the ISRCTN clinical trials registry (ISRCTN73266049, 08/04/2021: https://www.isrctn.com/ISRCTN73266049Test).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001f6f88b4836645fb27c96521252999Test
https://doaj.orgTest/article/8423a1b1fb244c3095332d39f8aab410

المؤلفون: Atsushi Kurata, Akihiko Gotoh, Masakatsu Takanashi, Masahiko Kuroda, Keiki Oikawa, Jun Matsubayashi, Kohsuke Kanekura, Toshitaka Nagao, Koji Fujita, Daigo Akahane, Narangerel Jigjidkhorloo, Oyundelger Norov, Hitoshi Endou

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports

مصطلحات موضوعية: Adult, Male, Prognostic factor, Amino Acid Transport Systems, Science, Gene Expression, Diseases, L-Type Amino Acid Transporter, Article, Large Neutral Amino Acid-Transporter 1, Malignant lymphoma, immune system diseases, Cell Line, Tumor, hemic and lymphatic diseases, Neutral amino acid transport, medicine, Humans, Aged, Cell Proliferation, Cancer, Aged, 80 and over, Multidisciplinary, biology, Drug discovery, Membrane transport protein, Cell growth, Gene Expression Profiling, Lymphoma, Non-Hodgkin, Middle Aged, Prognosis, medicine.disease, Lymphoma, Non-Hodgkin's lymphoma, Gene Expression Regulation, Neoplastic, Oncology, Amino Acid Transport System L, biology.protein, Cancer research, Medicine, Female, Transcriptome

الوصف: L-type neutral amino acid transporter 1 (LAT1) is a heterodimeric membrane transport protein involved in neutral amino acid transport. LAT1 is highly expressed in various malignant solid tumors and plays an essential role in cell proliferation. However, its role in malignant lymphoma remains unknown. Here, we evaluated LAT1 expression level in tissues from 138 patients with Non-Hodgkin lymphoma (NHL). Overexpression of LAT1 was confirmed in all types of NHL and we found that there is a significant correlation between the level of LAT1 expression and lymphoma grade. The LAT1 expression was higher in aggressive types of lymphomas when compared with static types of lymphomas, suggesting that active tumor proliferation requires nutrient uptake via LAT1. The expression level of LAT1 was inversely correlated with patients’ survival span. Furthermore, pharmacological inhibition of LAT1 by a specific inhibitor JPH203 inhibits lymphoma cell growth. In conclusion, our study demonstrated that LAT1 expression can be used as a prognostic marker for patients with NHL and targeting LAT1 by JPH203 can be a novel therapeutic modality for NHL.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e310310b3994aaafec3f03fff4b4794dTest
https://doaj.orgTest/article/254f7aaec22f4688a7954b03fd1e965b

المؤلفون: Hiroki Takagi, Miyuki Kajiwara, Irene Nowotny, Masanari Shiramoto, Hideya Muto, Wolfgang Schmider, Tatsuya Yoshihara

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Scientific Reports

مصطلحات موضوعية: Adult, Blood Glucose, Male, medicine.medical_specialty, Science, Drug development, Article, Insulin aspart, Young Adult, Glucose infusion, Double-Blind Method, Japan, Pharmacokinetics, Internal medicine, medicine, Humans, Hypoglycemic Agents, Potency, Biosimilar Pharmaceuticals, Insulin Aspart, Cross-Over Studies, Multidisciplinary, business.industry, Type 2 diabetes, Middle Aged, Crossover study, Healthy Volunteers, Confidence interval, Type 1 diabetes, Endocrinology, Therapeutic Equivalency, Pharmacodynamics, Medicine, Plasma insulin, Hormonal therapies, business, Biomarkers, medicine.drug

الوصف: This study compared the pharmacokinetic and glucodynamic profiles of biosimilar SAR341402 insulin aspart to Japan-approved insulin aspart (NovoRapid) in healthy Japanese males. In this single-center, randomized, double-blind, single-dose, two-period, crossover study, subjects received 0.3 U/kg of SAR341402 or NovoRapid before undergoing a 10 h euglycemic clamp procedure. Plasma insulin aspart concentrations and blood glucose levels were measured, and glucose infusion rates (GIRs) were assessed. Primary endpoints were maximum plasma insulin aspart concentration (INS-Cmax), area under the plasma insulin concentration–time curve to the last quantifiable concentration (INS-AUClast), area under the GIR–time curve during the clamp (GIR-AUC0–10 h), and maximum GIR (GIRmax). Forty subjects were randomized with 39 completing both treatment periods. Pharmacokinetic exposure showed a mean ratio between products of 1.00 (90% confidence interval [CI] 0.94–1.05) for INS-Cmax and 1.02 (90% CI 1.00–1.04) for INS-AUClast. Glucodynamic activity showed a mean ratio between products of 1.00 (95% CI 0.93–1.06) for GIR-AUC0–10 h and 1.01 (95% CI 0.95–1.08) for GIRmax. The 90% CIs for pairwise treatment ratios were within the predefined equivalence range of 0.80–1.25. Both treatments were well tolerated. We concluded that similar pharmacokinetic exposure and glucodynamic potency were shown for SAR341402 and NovoRapid in healthy Japanese males.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b35348be8171f6c2a176b21c9b5311Test
https://doaj.orgTest/article/91ffc0df4bcd43f98107227aa96b64ad

المؤلفون: Shu-Yang Li, Takaki Hiwasa, Bo-Shi Zhang, Tomoo Matsutani, Hirotaka Takizawa, Toshio Machida, Yasuo Iwadate, Seiichiro Mine, Eiichi Kobayashi, Yoichi Yoshida, Masaaki Kubota

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports

مصطلحات موضوعية: Adult, Male, Science, Inflammation, Article, Serology, Young Adult, Antigen, Diabetes mellitus, Plasminogen Activator Inhibitor 1, medicine, Humans, cardiovascular diseases, Aged, Autoantibodies, Aged, 80 and over, Multidisciplinary, biology, business.industry, Cerebral infarction, Autoantibody, Cerebral Infarction, Middle Aged, medicine.disease, Plaque, Atherosclerotic, Neurology, Risk factors, Ischemic Attack, Transient, Case-Control Studies, Immunology, biology.protein, Biomarker (medicine), Medicine, Female, medicine.symptom, Antibody, business, Biomarkers

الوصف: The presence of disease-specific antigens and autoantibodies in the sera of patients with atherosclerosis-related diseases has been widely reported and is considered to result from inflammation of the arterial wall and the involvement of immune factors. The aim of this study was to identify a novel antibody in patients with ischemic stroke by serological identification of antigens using recombinant cDNA expression cloning from patients who had a transient ischemic attack (TIA). We identified the serpin peptidase inhibitor, clade E member 1 (SERPINE1), as a candidate antigen. The serum anti-SERPINE1 antibody levels quantified using amplified luminescent proximity homogeneous assay-linked immunosorbent assay were significantly higher in patients with ischemic stroke, including those with acute cerebral infarction (aCI), TIA, and chronic cerebral infarction, than in healthy donors. The antibody levels were strongly associated with old age, female sex, and presence of hypertension, diabetes mellitus, and cardiovascular disease. Age and intima-media thickness of the carotid artery were positively correlated with antibody levels, which suggests that SERPINE1 may reflect the progression of atherosclerosis. In a multivariate analysis, SERPINE1 antibody level was an independent predictor of aCI. Thus, the serum levels of anti-SERPINE1 antibody could potentially serve as a biomarker of atherothrombotic infarction.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f4273226f29ef41681f3bc45446cbb7Test
https://doaj.orgTest/article/bd1aa44625364c7b85c95ab9f37de29f

المؤلفون: Jeong Min Lee, Jinwoo Hwang, Woo Chan Park, Ahwon Lee, Sung Hun Kim, Bong Joo Kang

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports

مصطلحات موضوعية: Adult, medicine.medical_specialty, Science, CD34, Contrast Media, Breast Neoplasms, Disease, Article, Correlation, Young Adult, Breast cancer, medicine, Humans, Effective diffusion coefficient, Prospective Studies, Receptor, Notch1, Notch 1, Tumor microenvironment, Multidisciplinary, business.industry, medicine.disease, Magnetic Resonance Imaging, Medicine, Female, Cancer imaging, Radiology, Neoplasm Recurrence, Local, business, Perfusion

الوصف: The purpose of this study is to investigate imaging characteristics of young age breast cancer (YABC) focusing on correlation with pathologic factors and association with disease recurrence. From January 2017 to December 2019, patients under 40 years old who were diagnosed as breast cancer were enrolled in this study. Morphologic analysis of tumor and multiple quantitative parameters were obtained from pre-treatment dynamic contrast enhanced breast magnetic resonance imaging (DCE-MRI). Tumor-stroma ratio (TSR), microvessel density (MVD) and endothelial Notch 1 (EC Notch 1) were investigated for correlation with imaging parameters. In addition, recurrence associated factors were assessed using both clinico-pathologic factors and imaging parameters. A total of 53 patients were enrolled. Several imaging parameters derived from apparent diffusion coefficient (ADC) histogram showed negative correlation with TSR; and there was negative correlation between MVD and Ve in perfusion analysis. There were nine cases of recurrences with median interval of 16 months. Triple negative subtype and low CD34 MVD positivity in Notch 1 hotspots showed significant association with tumor recurrence. Texture parameters reflecting tumor sphericity and homogeneity were also associated with disease recurrence. In conclusion, several quantitative MRI parameters can be used as imaging biomarkers for tumor microenvironment and can predict disease recurrence in YABC.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97b69531505948ee36102fcf5c24909Test
https://doaj.orgTest/article/38daee43de1f4e78bb28a4d4b3ebbeaf