Lack of Association between the Serotonin Transporter (5-HTT) and Serotonin Receptor (5-HT2A) Gene Polymorphisms with Smoking Behavior among Malaysian Malays
| العنوان: | Lack of Association between the Serotonin Transporter (5-HTT) and Serotonin Receptor (5-HT2A) Gene Polymorphisms with Smoking Behavior among Malaysian Malays |
|---|---|
| المؤلفون: | Imran Ahmad, Siew Hua Gan, Ruzilawati Abu Bakar, Nur Iwani A. Rozak |
| المصدر: | Scientia Pharmaceutica Volume 82 Issue 3 Pages 631-642 |
| بيانات النشر: | Austrian Pharmaceutical Society, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Genetics, education.field_of_study, Genetic polymorphism, biology, Rs6313, 5-HT2A receptor, Population, Pharmaceutical Science, 5-HTTLPR, PCR-RFLP, Genotype, biology.protein, behavior and behavior mechanisms, Allele, Malaysian Malays male, education, 5HT2A, Gene, Serotonin transporter, Research Article |
| الوصف: | An insertion/deletion polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) and a polymorphism (rs6313) in the serotonin 2A receptor gene (5-HT2A) have previously been linked to smoking behavior. The objective of this study was to determine the possible association of the 5-HTTLPR and 5-HT2A gene polymorphisms with smoking behavior within a population of Malaysian male smokers (n=248) and non-smokers (n=248). The 5-HTTLPR genotypes were determined using the polymerase chain reaction (PCR) and were classified as short (S) alleles or long (L) alleles. The 5HT2A genotypes were determined using PCR–restriction fragment length polymorphisms (PCR-RFLP). No significant differences in the distribution frequencies of the alleles were found between the smokers and the non-smokers for the 5-HTTLPR polymorphism (χ2 = 0.72, P> 0.05) or the 5HT2A polymorphism (χ2 = 0.73, P> 0.05). This is the first study conducted on Malaysian Malay males regarding the association of 5-HTTLPR and 5HT2A polymorphisms and smoking behavior. However, the genes were not found to be associated with smoking behavior in our population. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2218-0532 |
| DOI: | 10.3797/scipharm.1406-01 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610e3bc283442446c53934c79468a359Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....610e3bc283442446c53934c79468a359 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22180532 |
|---|---|
| DOI: | 10.3797/scipharm.1406-01 |