دورية أكاديمية
Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms
| العنوان: | Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms |
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| المؤلفون: | Citarella, Barbara Wanjiru, Kartsonaki, Christiana, Gonçalves, Bronner, Baruch, Joaquin, Escher, Martina, Ibañez Prada, Elsa Daniela, Rello, Jordi |
| المساهمون: | Institut Català de la Salut, Citarella BW, Gonçalves BP, Baruch J, Escher M ISARIC, Pandemic Sciences Institute, University of Oxford, Oxford, UK. Kartsonaki C MRC Population Health Research Unit, Clinical Trials Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. Ibáñez-Prada ED Universidad de La Sabana, Chía, Colombia. Clínica Universidad de La Sabana, Chía, Colombia. Rello J Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. CHU Nîmes, Nîmes, France, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | COVID-19 (Malaltia) - Epidemiologia, COVID-19 (Malaltia) - Factors de risc, Hospitals - Pacients, DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Signs and Symptoms, Respiratory, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Patient Care::Hospitalization, DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections, Other subheadings::Other subheadings::Other subheadings::/epidemiology, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors, ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::signos y síntomas respiratorios, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::asistencia al paciente::hospitalización, ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus, Otros calificadores::Otros calificadores::Otros calificadores::/epidemiología, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::probabilidad::riesgo::factores de riesgo |
| الوصف: | COVID-19; Respiratory symptoms; Risk factors ; COVID-19; Síntomas respiratorios; Factores de riesgo ; COVID-19; Símptomes respiratoris; Factors de risc ; Background COVID-19 is primarily known as a respiratory illness; however, many patients present to hospital without respiratory symptoms. The association between non-respiratory presentations of COVID-19 and outcomes remains unclear. We investigated risk factors and clinical outcomes in patients with no respiratory symptoms (NRS) and respiratory symptoms (RS) at hospital admission. Methods This study describes clinical features, physiological parameters, and outcomes of hospitalised COVID-19 patients, stratified by the presence or absence of respiratory symptoms at hospital admission. RS patients had one or more of: cough, shortness of breath, sore throat, runny nose or wheezing; while NRS patients did not. Results Of 178,640 patients in the study, 86.4 % presented with RS, while 13.6 % had NRS. NRS patients were older (median age: NRS: 74 vs RS: 65) and less likely to be admitted to the ICU (NRS: 36.7 % vs RS: 37.5 %). NRS patients had a higher crude in-hospital case-fatality ratio (NRS 41.1 % vs. RS 32.0 %), but a lower risk of death after adjusting for confounders (HR 0.88 [0.83–0.93]). Conclusion Approximately one in seven COVID-19 patients presented at hospital admission without respiratory symptoms. These patients were older, had lower ICU admission rates, and had a lower risk of in-hospital mortality after adjusting for confounders. ; This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome [215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z and 220757/Z/20/Z]; the Bill & Melinda Gates Foundation [OPP1209135]; the philanthropic support of the donors to the University of Oxford's COVID-19 Research Response Fund (0009109); grants from the National Institute for Health Research (NIHR; award CO–CIN-01/DH_/Department of Health/United Kingdom), the Medical Research Council (MRC; grant MC_PC_19059), and by the NIHR Health ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2405-8440 |
| العلاقة: | Heliyon;10(10); https://doi.org/10.1016/j.heliyon.2024.e29591Test; Citarella BW, Kartsonaki C, Ibáñez-Prada ED, Gonçalves BP, Baruch J, Escher M, et al. Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms. Heliyon. 2024 May 4;10(10):e29591.; https://hdl.handle.net/11351/11511Test |
| DOI: | 10.1016/j.heliyon.2024.e29591 |
| الإتاحة: | https://doi.org/10.1016/j.heliyon.2024.e29591Test https://hdl.handle.net/11351/11511Test |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5DBB7300 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2024.e29591 |