دورية أكاديمية
The efficacy of suppressive antibiotic treatment in patients managed non-operatively for periprosthetic joint infection and a draining sinus
| العنوان: | The efficacy of suppressive antibiotic treatment in patients managed non-operatively for periprosthetic joint infection and a draining sinus |
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| المؤلفون: | Lensen, Karel-Jan Dag François, Escudero-Sanchez, Rosa, Cobo, Javier, Trebše, Rihard, Gubavu, Camelia, Tedeschi, Sara, Rodríguez Pardo, Ma Dolores |
| المساهمون: | Institut Català de la Salut, Lensen KDF Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Escudero-Sanchez R, Cobo J Department of Infectious Diseases, Hospital Ramón y Cajal, IRYCIS, Madrid, Spain. Trebše R Service for Bone Infections, Valdoltra Orthopaedic Hospital, Ankaran, Slovenia. Gubavu C Department of Infectious and Tropical Diseases, CHR Orléans, Orléans, France. Tedeschi S Infectious Diseases Unit, Department of Medical and Surgical Sciences, University of Bologna Policlinico di Sant Orsola, Bologna, Italy. Rodriguez-Pardo D Servei de Malalties Infeccioses, Vall d'Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | Copernicus Publications |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Avaluació de resultats (Assistència sanitària), Articulacions artificials, Infecció, DISEASES::Bacterial Infections and Mycoses::Infection::Prosthesis-Related Infections, Other subheadings::Other subheadings::Other subheadings::/drug therapy, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome, ENFERMEDADES::infecciones bacterianas y micosis::infección::infecciones relacionadas con prótesis, Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento |
| الوصف: | Eficacia; Tratamiento antibiótico; Infección articular ; Eficàcia; Tractament antibiòtic; Infecció articular ; Efficacy; Antibiotic treatment; Joint infection ; Objectives: Patients with prosthetic joint infections (PJIs) not suitable for curative surgery may benefit from suppressive antibiotic therapy (SAT). However, the usefulness of SAT in cases with a draining sinus has never been investigated. Methods: A multicentre, retrospective observational cohort study was performed in which patients with a PJI and a sinus tract were eligible for inclusion if managed conservatively and if sufficient follow-up data were available (i.e. at least 2 years). SAT was defined as a period of > 6 months of oral antibiotic therapy. Results: SAT was initiated in 63 of 72 (87.5 %) included patients. Implant retention during follow-up was the same in patients receiving SAT vs. no SAT (79.4 % vs. 88.9 %; p=0.68). In total, 27 % of patients using SAT experienced side effects. In addition, the occurrence of prosthetic loosening in initially fixed implants, the need for surgical debridement, or the occurrence of bacteremia during follow-up could not be fully prevented with the use of SAT, which still occurred in 42 %, 6.3 %, and 3.2 % of cases, respectively. However, the sinus tract tended to close more often (42 % vs. 13 %; p=0.14), and a higher resolution of pain was observed (35 % vs. 14 %; p=0.22) in patients receiving SAT. Conclusions: SAT is not able to fully prevent complications in patients with a draining sinus. However, it may be beneficial in a subset of patients, particularly in those with pain or the hindrance of a draining sinus. A future prospective study, including a higher number of patients not receiving SAT, is needed. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2206-3552 |
| العلاقة: | Journal of Bone and Joint Infection;6(7); https://doi.org/10.5194/jbji-6-313-2021Test; Lensen KDF, Escudero-Sanchez R, Cobo J, Trebše R, Gubavu C, Tedeschi S, et al. The efficacy of suppressive antibiotic treatment in patients managed non-operatively for periprosthetic joint infection and a draining sinus. J Bone Jt Infect. 2021 Aug 17;6(7):313–319.; https://hdl.handle.net/11351/7407Test |
| DOI: | 10.5194/jbji-6-313-2021 |
| الإتاحة: | https://doi.org/10.5194/jbji-6-313-2021Test https://hdl.handle.net/11351/7407Test |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.6BB6BEAA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 22063552 |
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| DOI: | 10.5194/jbji-6-313-2021 |