Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes
| العنوان: | Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes |
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| المؤلفون: | Jed W. Fahey, Nils Wierup, Annika S. Axelsson, Shaji Chacko, Brig Mecham, Anders Rosengren, Hannah Nenonen, Jonathan M. J. Derry, Yunzhao Tang, Claes B. Wollheim, Emily Tubbs, Stephen H. Friend, Morey W. Haymond, Hindrik Mulder |
| المصدر: | Science Translational Medicine, Vol. 9, No 394 (2017) |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Blood Glucose, Male, medicine.medical_specialty, NF-E2-Related Factor 2, Type 2 diabetes, Biology, Carbohydrate metabolism, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Isothiocyanates, Diabetes mellitus, Internal medicine, medicine, Animals, Humans, Hypoglycemic Agents, Broccoli sprout extract, Obesity, ddc:612, Glycated Hemoglobin, General Medicine, medicine.disease, Metformin, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Glucose, chemistry, Gluconeogenesis, Diabetes Mellitus, Type 2, Liver, 030220 oncology & carcinogenesis, Sulfoxides, Female, Glycated hemoglobin, medicine.drug, Sulforaphane |
| الوصف: | A potentially useful approach for drug discovery is to connect gene expression profiles of disease-affected tissues ("disease signatures") to drug signatures, but it remains to be shown whether it can be used to identify clinically relevant treatment options. We analyzed coexpression networks and genetic data to identify a disease signature for type 2 diabetes in liver tissue. By interrogating a library of 3800 drug signatures, we identified sulforaphane as a compound that may reverse the disease signature. Sulforaphane suppressed glucose production from hepatic cells by nuclear translocation of nuclear factor erythroid 2-related factor 2 (NRF2) and decreased expression of key enzymes in gluconeogenesis. Moreover, sulforaphane reversed the disease signature in the livers from diabetic animals and attenuated exaggerated glucose production and glucose intolerance by a magnitude similar to that of metformin. Finally, sulforaphane, provided as concentrated broccoli sprout extract, reduced fasting blood glucose and glycated hemoglobin (HbA1c) in obese patients with dysregulated type 2 diabetes. |
| تدمد: | 1946-6242 1946-6234 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd51f66c5417f5048af1b90dbfa525dTest https://pubmed.ncbi.nlm.nih.gov/28664922Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....0bd51f66c5417f5048af1b90dbfa525d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19466242 19466234 |
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