التفاصيل البيبلوغرافية
| العنوان: |
Oncogenic lncRNA LINC00973 promotes Warburg effect by enhancing LDHA enzyme activity. |
| المؤلفون: |
Wang, Huili1 (AUTHOR), Lin, Kequan1,2 (AUTHOR), Zhu, Lin2 (AUTHOR), Zhang, Shaojun2 (AUTHOR), Li, Le2 (AUTHOR), Liao, Yilie2 (AUTHOR), Zhang, Baichao2 (AUTHOR), Yang, Ming1 (AUTHOR), Liu, Xinde2 (AUTHOR), Li, Lu2 (AUTHOR), Li, Shasha1 (AUTHOR), Yang, Liuqing2 (AUTHOR), Wang, Haiyan1 (AUTHOR), Wang, Qianyu2 (AUTHOR), Li, Haitao1 (AUTHOR), Fu, Suneng2 (AUTHOR), Zhang, Xiaorong3 (AUTHOR), Jiang, Peng2 (AUTHOR), Zhang, Qiangfeng Cliff2 (AUTHOR), Cheng, Jing1,4,5 (AUTHOR) jcheng@tsinghua.edu.cn |
| المصدر: |
Science Bulletin. Jul2021, Vol. 66 Issue 13, p1330-1341. 12p. |
| مصطلحات موضوعية: |
*GLYCOLYSIS, *NON-coding RNA, *LINCRNA, *LACTATE dehydrogenase, *ENZYMES, *TUMOR growth, *CELL proliferation |
| مستخلص: |
Through a large-scale functional screening, we identified a long non-coding RNA LINC00973 that is highly expressed in many types of human cancers and can significantly promote tumor cell proliferation in vitro and in vivo. Mechanistically, LINC00973 can bind to the key glycolysis enzyme LDHA (lactate dehydrogenase A) and enhance its enzyme activity, thereby accelerating the aerobic glycolysis of tumor cells, and ultimately promoting tumor cell proliferation. Clinically, high expression of LINC00973 is significantly associated with poor prognosis in many types of human cancers. Together, our work demonstrated that LINC00973 modulates a cancer-specific regulation mechanism for the Warburg effect and suggested a potential target against one of cancer's vulnerabilities for developing broad-acting anti-cancer therapies. [Display omitted] Aerobic glycolysis, also known as the Warburg effect, is a hallmark of cancer and essential for metabolism in malignancies, but its regulation and modulation in cancer cells remain poorly understood. Here, using large-scale functional screening, we identified a tumor-associated and broadly expressed oncogenic long noncoding RNA LINC00973. Notably, knocking down LINC00973 significantly inhibits the proliferation of multiple types of cancer cells and reduces tumor growth in vivo. Mechanistically, LINC00973 directly binds to lactate dehydrogenase A (LDHA), an essential glycolytic enzyme, and enhances its enzymatic activity, thereby promoting glycolysis. Clinically, high expression of LINC00973 is significantly associated with poor prognosis in many types of human cancers. This work demonstrates that LINC00973 modulates cancer-specific regulation of the Warburg effect, and may represent a potential target for broad-acting anti-cancer therapies. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
