التفاصيل البيبلوغرافية
| العنوان: |
Mitoxantrone targets both host and bacteria to overcome vancomycin resistance in Enterococcus faecalis. |
| المؤلفون: |
da Silva, Ronni A. G.1,2, Jun JieWong2,3, Antypas, Haris2, Pei Yi Choo2, Goh, Karlyn2,4, Jolly, Shreya2,4, Cui Liang1, Sing, Leona Tay Kwan1, Veleba, Mark2, Guangan Hu5, Jianzhu Chen1,5 jchen@mit.edu, Kline, Kimberly A.1,2,4,6 kimberly.kline@unige.ch |
| المصدر: |
Science Advances. 2/22/2023, Vol. 9 Issue 8, p1-18. 18p. |
| مصطلحات موضوعية: |
*LINEZOLID, *ANTIBIOTICS, *VANCOMYCIN resistance, *ENTEROCOCCUS faecalis, *MITOXANTRONE |
| مستخلص: |
The article presents the research regarding the antibiotic and immunological activity of the anticancer agent mitoxantrone (MTX) in vitro and in vivo against vancomycin-resistant Enterococcus faecalis (VRE). In vitro, MTX is a potent antibiotic against Gram-positive bacteria through the induction of reactive oxygen species and deoxyribonucleic acid damage. The results show that MTX represents a promising bacterium- and host-targeted therapeutic for overcoming vancomycin resistance. |
| قاعدة البيانات: |
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