التفاصيل البيبلوغرافية
| العنوان: |
The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes. |
| المؤلفون: |
Bender, Christine1, Rodriguez-Calvo, Teresa1,2, Amirian, Natalie1, Coppieters, Ken T.3, von Herrath, Matthias G.1,4 matthias@lji.org |
| المصدر: |
Science Advances. 10/14/2020, Vol. 6 Issue 42, p1-9. 9p. |
| مصطلحات موضوعية: |
*TYPE 1 diabetes, *T cells, *AUTOANTIBODIES, *PANCREAS, *ISLANDS of Langerhans, *CYTOTOXIC T cells |
| مستخلص: |
The article discusses the study of the healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes. Topics discusses include Preproinsulin (PPI) is presumably a crucial islet autoantigen found in patients with type1 diabetes (T1D); and this spatial cellular quantitation revealed unusually high frequencies of autoreactive CD8+ T cells supporting the hypothesis that PPI is indeed a key autoantigen. |
| قاعدة البيانات: |
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