Gut microbiome heritability is nearly universal but environmentally contingent
| العنوان: | Gut microbiome heritability is nearly universal but environmentally contingent |
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| المؤلفون: | Ran Blekhman, Tim L. Wango, Susan C. Alberts, Jean-Christophe Grenier, Luis B. Barreiro, Jacob B. Gordon, Trevor J. Gould, Niki H. Learn, Vania Yotova, Johannes R. Björk, Laura E. Grieneisen, David A. W. A. M. Jansen, R. S. Mututua, Jack A. Gilbert, Jenny Tung, J. Kinyua Warutere, Mauna Dasari, Laurence R. Gesquiere, Elizabeth A. Archie, Neil Gottel, Long'ida Siodi |
| المصدر: | Science. 373:181-186 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Aging, Genotype, Firmicutes, Environment, Biology, Feces, 03 medical and health sciences, 0302 clinical medicine, Animals, Humans, Microbiome, Social Behavior, Multidisciplinary, Bacteria, Bacteroidetes, Extramural, Host (biology), Heritability, Phenotype, Gut microbiome, Diet, Gastrointestinal Microbiome, Large sample, Actinobacteria, 030104 developmental biology, Evolutionary biology, Female, Seasons, 030217 neurology & neurosurgery, Papio |
| الوصف: | Baboons inform on human gut microbiota Commensal bacteria are found throughout an organism, but it is not known whether associations between gut bacteria and their host are heritable. Grieneisen et al. examined changes in the microbiomes of 585 wild baboons from fecal samples collected over 14 years (see the Perspective by Cortes-Ortiz and Amato). Almost all microbiome traits tested demonstrated some level of statistically significant heritability. Most heritability values were low but varied over time correlating with the age of the host. Baboons live in an environment similar to that postulated for early humans and have a microbiome similar to that of humans. Thus, this heritability of the microbiome may reflect similar genetic determinants in humans, for which similar datasets are not available. Science , aba5483, this issue p. 181 ; see also abj5287, p. 159 |
| تدمد: | 1095-9203 0036-8075 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63d6eccde636ae2869dc61d5b240adaTest https://doi.org/10.1126/science.aba5483Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b63d6eccde636ae2869dc61d5b240ada |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
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