A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types
| العنوان: | A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types |
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| المؤلفون: | Sean V. Tavtigian, Jane Weaver-Feldhaus, Keith D Harshman, Bruce E. Johnson, Alexander Kamb, Qingyun Liu, Mark H. Skolnick, Nelleke A. Gruis, Elisabeth Stockert, Rufus S. Day |
| المصدر: | Science. 264:436-440 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Tumor suppressor gene, Molecular Sequence Data, medicine.disease_cause, Frameshift mutation, Multiple Tumor Suppressor-1, Neoplasms, Proto-Oncogene Proteins, Tumor Cells, Cultured, medicine, Humans, Genes, Tumor Suppressor, Hereditary Melanoma, Melanoma, Protein Kinase Inhibitors, Cyclin-Dependent Kinase Inhibitor p16, Genetics, Multidisciplinary, Base Sequence, biology, Cyclin-dependent kinase 4, Cell Cycle, Cyclin-Dependent Kinase 4, Exons, Cell cycle, Cosmids, Cyclin-Dependent Kinases, Introns, Tumor Suppressor ARF, Mutation, biology.protein, Cancer research, Carrier Proteins, Chromosomes, Human, Pair 9, Carcinogenesis, Gene Deletion |
| الوصف: | A putative tumor suppressor locus on the short arm of human chromosome 9 has been localized to a region of less than 40 kilobases by means of homozygous deletions in melanoma cell lines. This region contained a gene, Multiple Tumor Suppressor 1 (MTS1), that encodes a previously identified inhibitor (p16) of cyclin-dependent kinase 4. MTS1 was homozygously deleted at high frequency in cell lines derived from tumors of lung, breast, brain, bone, skin, bladder, kidney, ovary, and lymphocyte. Melanoma cell lines that carried at least one copy of MTS1 frequently carried nonsense, missense, or frameshift mutations in the gene. These findings suggest that MTS1 mutations are involved in tumor formation in a wide range of tissues. |
| تدمد: | 1095-9203 0036-8075 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e58bcad11c36232f8890012d1b22bbaTest https://doi.org/10.1126/science.8153634Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2e58bcad11c36232f8890012d1b22bba |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
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