Nanotubular Highways for Intercellular Organelle Transport
| العنوان: | Nanotubular Highways for Intercellular Organelle Transport |
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| المؤلفون: | Paul Walther, Ivanka Markovic, Amin Rustom, Hans-Hermann Gerdes, Rainer Saffrich |
| المصدر: | Science. 303:1007-1010 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Recombinant Fusion Proteins, Green Fluorescent Proteins, Protein Prenylation, Synaptophysin, Cell Communication, Endosomes, Plasmodesma, Biology, PC12 Cells, Cell Line, 03 medical and health sciences, 0302 clinical medicine, Cell–cell interaction, Organelle, Animals, Pseudopodia, Fluorescent Dyes, 030304 developmental biology, Organelles, 0303 health sciences, Microscopy, Video, Multidisciplinary, Intercellular transport, Cell Membrane, Membrane Proteins, Biological Transport, Membrane nanotube, Carbocyanines, Actins, Endocytosis, Rats, Cell biology, Transport protein, Luminescent Proteins, Protein Transport, Microscopy, Fluorescence, Microscopy, Electron, Scanning, Protein prenylation, Cell Surface Extensions, 030217 neurology & neurosurgery, Cytoneme |
| الوصف: | Cell-to-cell communication is a crucial prerequisite for the development and maintenance of multicellular organisms. To date, diverse mechanisms of intercellular exchange of information have been documented, including chemical synapses, gap junctions, and plasmodesmata. Here, we describe highly sensitive nanotubular structures formed de novo between cells that create complex networks. These structures facilitate the selective transfer of membrane vesicles and organelles but seem to impede the flow of small molecules. Accordingly, we propose a novel biological principle of cell-to-cell interaction based on membrane continuity and intercellular transfer of organelles. |
| تدمد: | 1095-9203 0036-8075 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905dd506cda7e641791ce171650ec7b5Test https://doi.org/10.1126/science.1093133Test |
| رقم الانضمام: | edsair.doi.dedup.....905dd506cda7e641791ce171650ec7b5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
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