Survivin Reads Phosphorylated Histone H3 Threonine 3 to Activate the Mitotic Kinase Aurora B
| العنوان: | Survivin Reads Phosphorylated Histone H3 Threonine 3 to Activate the Mitotic Kinase Aurora B |
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| المؤلفون: | Kelly, A. E., Ghenoiu, C., Xue, J. Z., Zierhut, C., Kimura, Hiroshi, Funabiki, H. |
| المصدر: | Science. 330:235-239 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Histones/*metabolism, Mitosis, Xenopus Proteins/chemistry/*metabolism, Molecular Sequence Data, Aurora B kinase, Chromosomal Proteins, Non-Histone/metabolism, macromolecular substances, Biology, Article, Chromatin/metabolism, Xenopus laevis, Histone H3, Aurora Kinases, Animals, Protein Interaction Domains and Motifs, Phosphorylation, Kinase activity, Chromosomes/*metabolism, Spindle Apparatus/metabolism, Multidisciplinary, Molecular biology, Spindle apparatus, Enzyme Activation, enzymes and coenzymes (carbohydrates), Histone, Histone phosphorylation, Chromosome passenger complex, Centromere/metabolism, biology.protein, Protein-Serine-Threonine Kinases/*metabolism, Aurora Kinase B, Threonine/metabolism, Cell Division, Protein Binding |
| الوصف: | Location, Location, Location Cell division is orchestrated by a complex signaling pathway that ensures the correct segregation of newly replicated chromosomes to the two daughter cells. The pathway is controlled in part by restricting the activity of critical regulators to specific subcellular locations. For example, the chromosomal passenger complex (CPC) is recruited to chromosomes during mitosis where it oversees kinetochore activity and cytokinesis (see Perspective by Musacchio ). Wang et al. (p. 231 , published online 12 August), Kelly et al. (p. 235 , published online 12 August), and Yamagishi et al. (p. 239 ) now show that the phosphorylation of the chromatin protein, histone H3, acts to bring the CPC to chromosomes, thereby activating its aurora B kinase subunit. The Survivin subunit of CPC binds specifically to phosphorylated H3, with the phosphorylation at centromeres being carried out by the mitosis-specific kinase, haspin. Furthermore, Bub1 phosphorylation of histone H2A recruits shugoshin, a centromeric CPC adapter. Thus, these two histone marks in combination define the inner centromere. |
| تدمد: | 1095-9203 0036-8075 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85bfa8fb568dc0ce377e4f2b6610b5fTest https://doi.org/10.1126/science.1189505Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b85bfa8fb568dc0ce377e4f2b6610b5f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
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