Role of Polo-like Kinase CDC5 in Programming Meiosis I Chromosome Segregation
| العنوان: | Role of Polo-like Kinase CDC5 in Programming Meiosis I Chromosome Segregation |
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| المؤلفون: | Angelika Amon, Brian H. Lee |
| المصدر: | Science. 300:482-486 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Saccharomyces cerevisiae Proteins, Cdc20 Proteins, Condensin, Centromere, Cell Cycle Proteins, Saccharomyces cerevisiae, Chromatids, Protein Serine-Threonine Kinases, Chromosomal crossover, Chromosome segregation, Chromosome Segregation, Homologous chromosome, Interkinesis, Phosphorylation, Kinetochores, Metaphase, Cell Nucleus, Genetics, Multidisciplinary, Cohesin, biology, Synapsis, Nuclear Proteins, Cell biology, Securin, Monopolin, Meiosis, biology.protein, Chromosomes, Fungal, Anaphase, Protein Kinases |
| الوصف: | Meiosis is a specialized cell division in which two chromosome segregation phases follow a single DNA replication phase. The budding yeast Polo-like kinase Cdc5 was found to be instrumental in establishing the meiosis I chromosome segregation program. Cdc5 was required to phosphorylate and remove meiotic cohesin from chromosomes. Furthermore, in the absence of CDC5 kinetochores were bioriented during meiosis I, and Mam1, a protein essential for coorientation, failed to associate with kinetochores. Thus, sister-kinetochore coorientation and chromosome segregation during meiosis I are coupled through their dependence on CDC5 . |
| تدمد: | 1095-9203 0036-8075 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005d12aa59df87082a76fd6baa420badTest https://doi.org/10.1126/science.1081846Test |
| رقم الانضمام: | edsair.doi.dedup.....005d12aa59df87082a76fd6baa420bad |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
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