دورية أكاديمية
Cytokines drive the formation of memory-like NK cell subsets via epigenetic rewiring and transcriptional regulation.
| العنوان: | Cytokines drive the formation of memory-like NK cell subsets via epigenetic rewiring and transcriptional regulation. |
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| المؤلفون: | Foltz, Jennifer A, Tran, Jennifer, Wong, Pamela, Fan, Changxu, Schmidt, Evelyn, Fisk, Bryan, Becker-Hapak, Michelle, Russler-Germain, David A, Johnson, Jeanette, Marin, Nancy D, Cubitt, Celia C, Pence, Patrick, Rueve, Joseph, Pureti, Sushanth, Hwang, Kimberly, Gao, Feng, Zhou, Alice Y, Foster, Mark, Schappe, Timothy, Marsala, Lynne, Berrien-Elliott, Melissa M, Cashen, Amanda F, Bednarski, Jeffrey J, Fertig, Elana, Griffith, Obi L, Griffith, Malachi, Wang, Ting, Petti, Allegra A, Fehniger, Todd A |
| المصدر: | Sci Immunol ; ISSN:2470-9468 ; Volume:9 ; Issue:96 |
| بيانات النشر: | Atypon |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| الوصف: | Activation of natural killer (NK) cells with the cytokines interleukin-12 (IL-12), IL-15, and IL-18 induces their differentiation into memory-like (ML) NK cells; however, the underlying epigenetic and transcriptional mechanisms are unclear. By combining ATAC-seq, CITE-seq, and functional analyses, we discovered that IL-12/15/18 activation results in two main human NK fates: reprogramming into enriched memory-like (eML) NK cells or priming into effector conventional NK (effcNK) cells. eML NK cells had distinct transcriptional and epigenetic profiles and enhanced function, whereas effcNK cells resembled cytokine-primed cNK cells. Two transcriptionally discrete subsets of eML NK cells were also identified, eML-1 and eML-2, primarily arising from CD56bright or CD56dim mature NK cell subsets, respectively. Furthermore, these eML subsets were evident weeks after transfer of IL-12/15/18-activated NK cells into patients with cancer. Our findings demonstrate that NK cell activation with IL-12/15/18 results in previously unappreciated diverse cellular fates and identifies new strategies to enhance NK therapies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1126/sciimmunol.adk4893Test; https://pubmed.ncbi.nlm.nih.gov/38941480Test |
| DOI: | 10.1126/sciimmunol.adk4893 |
| الإتاحة: | https://doi.org/10.1126/sciimmunol.adk4893Test https://pubmed.ncbi.nlm.nih.gov/38941480Test |
| رقم الانضمام: | edsbas.59929639 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1126/sciimmunol.adk4893 |
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