دورية أكاديمية
Rationale and design of the ETN-STEP (Early administration of Tirofiban in mid to high risk patients with non-ST elevation acute coronary syndrome referred for percutaneous coronary intervention) project: A multi-center, randomized, controlled cl
| العنوان: | Rationale and design of the ETN-STEP (Early administration of Tirofiban in mid to high risk patients with non-ST elevation acute coronary syndrome referred for percutaneous coronary intervention) project: A multi-center, randomized, controlled cl |
|---|---|
| المؤلفون: | Li, Jian-Ping, Liu, Qun, Huo, Yong |
| المساهمون: | Huo, Y (reprint author), Peking Univ, Dept Cardiol, Hosp 1, 8 Xishuku St, Beijing 100034, Peoples R China., Peking Univ, Dept Cardiol, Hosp 1, Beijing 100034, Peoples R China., Beijing Hypertens League Inst, Beijing 100040, Peoples R China., Peking Univ, Dept Cardiol, Hosp 1, 8 Xishuku St, Beijing 100034, Peoples R China. |
| المصدر: | SCI ; PubMed |
| بيانات النشر: | journal of geriatric cardiology |
| سنة النشر: | 2012 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | Acute coronary syndrome, Percutaneous coronary intervention, Glycoprotein IIb/IIIa receptor, Tirofiban, Thrombolysis in myocardial infarction, GLYCOPROTEIN IIB/IIIA INHIBITORS, METAANALYSIS |
| الوصف: | As a member of Glycoprotein IIb/IIIa (GP IIb/IIIa) inhibitors, Tirofiban had been shown to improve myocardial reperfusion and clinical outcomes in patients undergoing percutaneous coronary intervention (PCI), but the optimal timing of administration of Tirofiban remains unclear. In order to compare the effects of upstream versus downstream administration of Tirofiban in Chinese patients with mid to high risk, non-ST elevation acute coronary syndrome (ACS) referred for PCI, a multi-center, randomized, controlled, prospective study will be conducted. A total of 500 mid to high risk, non-ST-segment elevation myocardial infarction (NSTEMI) ACS patients will be recruited for this study. Patients will be randomized to Tirofiban upstream administration group (initiated 12 h before PCI) and Tirofiban downstream administration group (initiated at cath-lab after angiography). Thrombolysis in myocardial infarction (TIMI) flow grades, TIMI myocardial perfusion grades (TMPG), and Corrected TIMI frame counting (CTFC) before and after PCI, as well as clinical outcomes during the hospital stay, and within 30 days after PCI will be compared between the two groups. This study will provide evidence on the optimal timing for initiating administration of Tirofiban in mid to high NSTEMI ACS subjects undergoing PCI. J Geriatr Cardiol 2012; 9: 375-378. doi:10.3724/SP.J.1263.2012.02272 ; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000316609200009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Test ; Cardiac & Cardiovascular Systems ; Geriatrics & Gerontology ; SCI(E) ; PubMed ; 中国科学引文数据库(CSCD) ; 0 ; ARTICLE ; 4 ; 375-378 ; 9 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 1671-5411 |
| العلاقة: | JOURNAL OF GERIATRIC CARDIOLOGY.2012,9,(4),375-378.; 656920; http://hdl.handle.net/20.500.11897/304197Test; WOS:000316609200009 |
| DOI: | 10.3724/SP.J.1263.2012.02272 |
| الإتاحة: | https://doi.org/20.500.11897/304197Test https://doi.org/10.3724/SP.J.1263.2012.02272Test https://hdl.handle.net/20.500.11897/304197Test |
| رقم الانضمام: | edsbas.3072A3D9 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16715411 |
|---|---|
| DOI: | 10.3724/SP.J.1263.2012.02272 |