دورية أكاديمية
Practical reconstruction method for bioluminescence tomography
| العنوان: | Practical reconstruction method for bioluminescence tomography |
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| المؤلفون: | Cong, WX, Wang, G, Kumar, D, Liu, Y, Jiang, M, Wang, LV, Hoffman, EA, McLennan, G, McCray, PB, Zabner, J, Cong, A |
| المساهمون: | Cong, WX (reprint author), Univ Iowa, Dept Radiol, Bioluminescence Tomog Lab, Iowa City, IA 52242 USA., Univ Iowa, Dept Radiol, Bioluminescence Tomog Lab, Iowa City, IA 52242 USA., Peking Univ, LMAM, Sch Math Sci, Beijing 100871, Peoples R China., Texas A&M Univ, Opt Imaging Lab, Dept Biomed Engn, College Stn, TX 77843 USA., Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA., Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA., Univ Iowa, Program Gene Therapy, Iowa City, IA 52242 USA. |
| المصدر: | SCI ; EI |
| بيانات النشر: | 光学快报 |
| سنة النشر: | 2005 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | OPTICAL-PROPERTIES, SCATTERING MEDIA, GENE-EXPRESSION, REPORTER GENE, LIVING MICE, LIGHT, PROPAGATION, TISSUE, MODEL |
| الوصف: | Bioluminescence tomography (BLT) is used to localize and quantify bioluminescent sources in a small living animal. By advancing bioluminescent imaging to a tomographic framework, it helps to diagnose diseases, monitor therapies and facilitate drug development. In this paper, we establish a direct linear relationship between measured surface photon density and an unknown bioluminescence source distribution by using a finite- element method based on the diffusion approximation to the photon propagation in biological tissue. We develop a novel reconstruction algorithm to recover the source distribution. This algorithm incorporates a priori knowledge to define the permissible source region in order to enhance numerical stability and efficiency. Simulations with a numerical mouse chest phantom demonstrate the feasibility of the proposed BLT algorithm and reveal its performance in terms of source location, density, and robustness against noise. Lastly, BLT experiments are performed to identify the location and power of two light sources in a physical mouse chest phantom. (c) 2005 Optical Society of America ; Optics ; SCI(E) ; EI ; 0 ; ARTICLE ; 18 ; 6756-6771 ; 13 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 1094-4087 |
| العلاقة: | OPTICS EXPRESS.2005,13,(18),6756-6771.; 988181; http://hdl.handle.net/20.500.11897/399129Test; WOS:000231719600009 |
| DOI: | 10.1364/OPEX.13.006756 |
| الإتاحة: | https://doi.org/20.500.11897/399129Test https://doi.org/10.1364/OPEX.13.006756Test https://hdl.handle.net/20.500.11897/399129Test |
| رقم الانضمام: | edsbas.CB44EDB9 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 10944087 |
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| DOI: | 10.1364/OPEX.13.006756 |