دورية أكاديمية
The Role of HE4 in Ovarian Cancer: Inhibiting Tumour Cell Proliferation and Metastasis
| العنوان: | The Role of HE4 in Ovarian Cancer: Inhibiting Tumour Cell Proliferation and Metastasis |
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| المؤلفون: | Gao, L., Cheng, H. Y., Dong, L., Ye, X., Liu, Y. N., Chang, X. H., Cheng, Y. X., Chen, J., Ma, R. Q., Cui, H. |
| المساهمون: | Cui, H (reprint author), Peking Univ, Peoples Hosp, Gynecol Oncol Ctr, 11 Xi Zhi Men S St, Beijing 100044, Peoples R China., Peking Univ, Peoples Hosp, Gynecol Oncol Ctr, Beijing 100044, Peoples R China., Peking Univ, Peoples Hosp, Gynecol Oncol Ctr, 11 Xi Zhi Men S St, Beijing 100044, Peoples R China. |
| المصدر: | SCI |
| بيانات النشر: | journal of international medical research |
| سنة النشر: | 2011 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | HUMAN EPIDIDYMIS PROTEIN 4 (HE4), OVARIAN CANCER, APOPTOSIS, CELL PROLIFERATION, METASTASIS, PROTEINASE-INHIBITORS, ENDOMETRIOTIC CYSTS, PROTEASE INHIBITOR, PELVIC MASS, SERUM HE-4, BIOMARKER, EXPRESSION, CARCINOMA, MULTIPLE, MARKER |
| الوصف: | As a promising biomarker, human epididymis protein 4 (HE4) has been widely used for the early detection and differential diagnosis of ovarian cancer. This study evaluated the function of HE4 in the carcinogenesis and progression of ovarian cancer. An enzyme immunometric assay, used to detect HE4 in the serum of ovarian cancer patients, showed that the protein could discriminate between malignant and benign ovarian tumours with high specificity. An exogenous HE4 gene was transfected into ovarian cancer cell lines and an immortalized ovarian epithelial cell line. Compared with the controls, HE4 overexpression significantly promoted cell apoptosis and adhesion. Overexpression of HE4 also led to significant inhibition of cell proliferation, migration and invasiveness in vitro, as well as xenograft tumour formation in vivo. This is the first report to demonstrate the functional importance of HE4 in multiple cellular processes and indicates that HE4 may play a protective role in the progression of ovarian cancer. ; Medicine, Research & Experimental ; Pharmacology & Pharmacy ; SCI(E) ; 6 ; 5 ; 1645-1660 ; 39 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0300-0605 |
| العلاقة: | JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.2011,39,(5),1645-1660.; 899539; http://hdl.handle.net/20.500.11897/308414Test; WOS:000297532400007 |
| الإتاحة: | https://doi.org/20.500.11897/308414Test https://hdl.handle.net/20.500.11897/308414Test |
| رقم الانضمام: | edsbas.2DBF0538 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 03000605 |
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