دورية أكاديمية
The optimal single-dose regimen of rasburicase for management of tumour lysis syndrome in children and adults: a systematic review and meta-analysis
| العنوان: | The optimal single-dose regimen of rasburicase for management of tumour lysis syndrome in children and adults: a systematic review and meta-analysis |
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| المؤلفون: | Yu, X., Liu, L., Nie, X., Li, J., Zhang, J., Zhao, L., Wang, X. |
| المساهمون: | Capital Med Univ, Dept Pharm, Beijing Childrens Hosp, 56 Nanlishi Rd, Beijing 100045, Peoples R China., Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Pharm Adm & Clin Pharm, Beijing, Peoples R China. |
| المصدر: | SCI |
| بيانات النشر: | JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS |
| سنة النشر: | 2017 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | adults, children, meta-analysis, rasburicase, single-dose regimen, tumour lysis syndrome, RECOMBINANT URATE OXIDASE, 6 MG, CANCER-PATIENTS, HYPERURICEMIA, RISK, PREVENTION, PATHOGENESIS, EFFICACY, LYMPHOMA |
| الوصف: | What is known and objectiveTo perform a meta-analysis exploring the optimal single-dose regimen for managing tumour lysis syndrome (TLS) in children and adults with haematological malignancies. MethodsWe systematically searched PubMed, MEDLINE, Web of Science, the Cochrane Library and the ClinicalTrials.gov website for studies regarding single-dose rasburicase in paediatric and adult patients with TLS. Data were analysed using Open MetaAnalyst statistical software. ResultsFifteen adult studies (fourteen retrospective studies and one randomized controlled trial) and four observational studies using children were extracted, with a total of 906 and 92 subjects, respectively. Single doses of 1 5, 3, 4 5, 6, 7 5 mg and weight-based single doses of 0 05 and 0 15 mg/kg were compared. The response rate for 6, 7 5 mg and 0 15 mg/kg single doses was 90% (95% CI: 0 825-0 974), 98 6% (95% CI: 0 957-1 015) and 93 6% (95% CI: 0 864-1 007), respectively, and higher than other dosing regimens tested. The single doses of 6 mg and 0 15 mg/kg rasburicase decreased uric acid levels more than the other regimens, and the mean uric acid reduction was 8 45 mg/dL (95% CI, 7 51-9 38) and 10 mg/dL (95% CI, 8 58-11 42), respectively. What is new and conclusionOur meta-analysis revealed that, for adult patients, a single 6 mg rasburicase dose is sufficient to normalize and sustain lower uric acid and creatinine levels in adults with TLS. This dose, therefore, balances cost and efficacy of treatment. The 3- and 4 5-mg single dose can be considered if the baseline uric acid level <12 mg/dL, with close monitoring of clinical and biochemical parameters, and repeat dosing if required. The 1 5 mg and 0 15 mg/kg single dose were sufficient to manage TLS in children. ; SCI(E) ; REVIEW ; 1 ; 18-26 ; 42 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0269-4727 1365-2710 |
| العلاقة: | JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS.2017,42(1),18-26.; 1910067; http://hdl.handle.net/20.500.11897/475524Test; WOS:000392503900003 |
| DOI: | 10.1111/jcpt.12479 |
| الإتاحة: | https://doi.org/20.500.11897/475524Test https://doi.org/10.1111/jcpt.12479Test https://hdl.handle.net/20.500.11897/475524Test |
| رقم الانضمام: | edsbas.5A1F08B9 |
| قاعدة البيانات: | BASE |
| تدمد: | 02694727 13652710 |
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| DOI: | 10.1111/jcpt.12479 |