دورية أكاديمية
Expression of microRNA-122 contributes to apoptosis in H9C2 myocytes
| العنوان: | Expression of microRNA-122 contributes to apoptosis in H9C2 myocytes |
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| المؤلفون: | Huang, Xiaoyan, Huang, Fang, Yang, Deye, Dong, Fengquan, Shi, Xiangxiang, Wang, Hongyu, Zhou, Xi, Wang, Suyun, Dai, Shengchuan |
| المساهمون: | Yang, DY (reprint author), Wenzhou Med Coll, Inst Cardiovasc Biol & Gene, Affiliated Hosp 1, Div Cardiol, Wenzhou 325000, Peoples R China., Wenzhou Med Coll, Inst Cardiovasc Biol & Gene, Affiliated Hosp 1, Div Cardiol, Wenzhou 325000, Peoples R China., Univ Pittsburgh, Med Ctr, Cardiovasc Inst, Div Cardiol, Pittsburgh, PA USA., Peking Univ, Shougang Hosp, Dept Vasc Med, Beijing 100871, Peoples R China. |
| المصدر: | SCI |
| بيانات النشر: | journal of cellular and molecular medicine |
| سنة النشر: | 2012 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | miR-122, differential expression, ventricular septum defect, apoptosis, HAND2, CONGENITAL HEART-DISEASE, TRANSCRIPTION FACTOR, CANCER-CELLS, GENE, RNA, SENSITIVITY, DEFECTS, MIRNAS, DHAND |
| الوصف: | The microRNAs (miRNAs) can post-transcriptionally regulate gene expression and heart development. The Pax-8 gene knockout mice have apparent heart abnormalities. This study investigated the role of miRNAs in regulation of cardiac apoptosis and development in the knockout mice. MicroRNA microarrays demonstrated differential expression of microRNAs between Pax-8-/- and Pax-8+/- mice, confirmed by real-time PCR. The miR-122 was up-regulated by 1.92 folds in Pax-8-/- mice. There were ventricular septum defects in Pax-8-/- mice, and increased numbers of apoptotic cells in the left ventricular wall and interventricular septum in Pax-8-/- mice. In H9C2 myocytes, treatment with miR-122 mimics or miR-122 inhibitor affects the expression of CCK-8 and activity of Caspase-3. The miR-122 is up-regulated in the myocytes of Pax-8-/- mice and may participate in the apoptotic gene expression and pathogenesis of heart development defect. ; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000310555200008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Test ; Cell Biology ; Medicine, Research & Experimental ; SCI(E) ; 7 ; ARTICLE ; 11 ; 2637-2646 ; 16 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 1582-1838 |
| العلاقة: | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE.2012,16,(11),2637-2646.; 863206; http://hdl.handle.net/20.500.11897/230428Test; WOS:000310555200008 |
| DOI: | 10.1111/j.1582-4934.2012.01577.x |
| الإتاحة: | https://doi.org/20.500.11897/230428Test https://doi.org/10.1111/j.1582-4934.2012.01577.xTest https://hdl.handle.net/20.500.11897/230428Test |
| رقم الانضمام: | edsbas.466C9B4A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15821838 |
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| DOI: | 10.1111/j.1582-4934.2012.01577.x |