T Cells Recognizing Multiple Peptides of Myelin Basic Protein are Found in Blood and Enriched in Cerebrospinal Fluid in Optic Neuritis and Multiple Sclerosis
| العنوان: | T Cells Recognizing Multiple Peptides of Myelin Basic Protein are Found in Blood and Enriched in Cerebrospinal Fluid in Optic Neuritis and Multiple Sclerosis |
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| المؤلفون: | Tommy Olsson, V. Kostulas, Bo Höjeberg, Mats Söderström, B.‐L. Li, Jia-Bin Sun, Hans Link, Sten Fredrikson |
| المصدر: | Scandinavian Journal of Immunology. 37:355-368 |
| بيانات النشر: | Wiley, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Adult, Male, Multiple Sclerosis, Optic Neuritis, T-Lymphocytes, Immunology, Immunodominance, Cross Reactions, Lymphocyte Activation, Epitopes, Interferon-gamma, Myelin, Cerebrospinal fluid, Antigen, medicine, Humans, Optic neuritis, Cerebrospinal Fluid, Autoimmune disease, biology, business.industry, Multiple sclerosis, Myelin Basic Protein, General Medicine, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Myelin basic protein, medicine.anatomical_structure, biology.protein, Female, Peptides, business |
| الوصف: | The cause of multiple sclerosis (MS) is unknown. Recently reported abnormal T-cell responses to several myelin proteins and myelin basic protein (MBP) peptides in peripheral blood constitute one line of evidence that autoimmune mechanisms could be involved in the pathogenesis of the disease. Monosymptomatic unilateral optic neuritis (ON) is a common first manifestation of MS and important to examine for a possible restriction of the T-cell repertoire early in the disease. T-cell activities to MBP and the MBP amino acid sequences 63-88, 110-128 and 148-165 were examined by short-term cultures of mononuclear cells from cerebrospinal fluid (CSF) and blood in the presence of these antigens, and subsequent detection and counting of antigen-specific T cells that responded by interferon-gamma (IFN-gamma) secretion. Most patients with MS and ON had MBP and MBP peptide-reactive T cells in CSF, amounting to mean values of between about 1 per 2000 and 1 per 7000 CSF cells and without immunodominance for any of the peptides. Numbers were 10-fold to 100-fold lower in the patients' blood. Values were similar in ON and MS, and no evidence was obtained for a more restricted T-cell repertoire in ON. The MBP peptide-recognizing T-cell repertoire was different in CSF than in blood in individual patients with ON and MS, thereby giving further evidence for an autonomy of the autoimmune T-cell response in the CSF compartment. No relations were observed between numbers of autoreactive T cells and presence of oligoclonal IgG bands in CSF or abnormalities on magnetic resonance imaging of the brain in ON or clinical variables of MS. The high numbers of MBP and MBP peptide-reactive T cells could play a role in the pathogenesis of ON via secretion of effector molecules, one of them being IFN-gamma, as well as in the transfer of ON to MS. |
| تدمد: | 1365-3083 0300-9475 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b958319dd8c4b304f0049c864a756eeTest https://doi.org/10.1111/j.1365-3083.1993.tb02565.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....0b958319dd8c4b304f0049c864a756ee |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13653083 03009475 |
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