Screening for thyroid disorders in asymptomatic adults from Brazilian populations
| العنوان: | Screening for thyroid disorders in asymptomatic adults from Brazilian populations |
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| المؤلفون: | Isabela M. Benseñor |
| المصدر: | Sao Paulo Medical Journal v.120 n.5 2002 São Paulo medical journal Associação Paulista de Medicina instacron:APM Sao Paulo Medical Journal, Volume: 120, Issue: 5, Pages: 146-151, Published: JUL 2002 São Paulo Medical Journal, Vol 120, Iss 5, Pp 146-151 |
| بيانات النشر: | FapUNIFESP (SciELO), 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Male, Pediatrics, endocrine system diseases, lcsh:Medicine, Thyrotropin, Thyroid Function Tests, Hyperthyroidism, Risk Factors, Prevalence, Mass Screening, Medicine, Myocardial infarction, Doenças da tireóide, Subclinical infection, Thyroid, Disorders, medicine.diagnostic_test, General Medicine, Cardiovascular disease, medicine.anatomical_structure, Sintomas, Female, medicine.symptom, Brazil, hormones, hormone substitutes, and hormone antagonists, Adult, endocrine system, medicine.medical_specialty, Subclinical, Thyroid function tests, Asymptomatic, Hypothyroidism, Thyroid-stimulating hormone, Internal medicine, Diabetes mellitus, Humans, Hipotireoidismo, Aged, Doenças cardiovasculares, business.industry, lcsh:R, Subclínico, medicine.disease, Thyroid Diseases, Thyroid disorder, Thyroxine, Endocrinology, Symptoms, business |
| الوصف: | Advances in thyroid disorder diagnosis have created new thyroid disorder categories such as subclinical hyperthyroidism and subclinical hypothyroidism. In the 1980s, immunometric assaying for thyroid stimulating hormone (TSH) emerged and became defined as the most cost-effective test in thyroid disorder screening. The second step in the screening of thyroid disorders is to determine free thyroxine (FT4), and cost-effective methods for its detection are now available. Using TSH and FT4, it is possible to determine four situations: clinical hyperthyroidism, clinical hypothyroidism, subclinical hyperthyroidism and subclinical hypothyroidism. Subclinical hypothyroidism can be a strong indicator of risk for atherosclerosis and myocardial infarction in elderly women. Cardiovascular mortality among Brazilian women is one of the highest in the Western world. The best-known risk factors for cardiovascular diseases are high blood pressure, smoking, diabetes, and hypercholesterolemia. Although these are recognized as primary risk factors, there are other risk factors that could be identified as primordial risk factors. This may be the case for subclinical hypothyroidism. Early detection of thyroid disorders in women over fifty could be a highly cost-effective option in the prevention of cardiovascular disorders among Brazilian women. O avanço no diagnóstico das doenças da tireóide criou uma nova categoria de doenças representada pelo hipertireoidismo e hipotireoidismo subclínicos. Na década de 80, surgiram os métodos imunométricos para dosagem da tireotropina (TSH) considerados os mais custo-efetivos para o rastreamento de doenças da tireóide. O segundo passo no rastreamento das doenças da tireóide é a determinação dos níveis séricos de tiroxina, e vários métodos custo-efetivos estão disponíveis no mercado. Usando-se o TSH e a tiroxina é possível diagnosticar quatro situações clínicas: hipotireoidismo e hipertireoidismo e hipotireoidismo subclínico e hipertireoidismo subclínico. O hipotireoidismo subclínico pode ser um fator de risco muito importante para doença cardiovascular em mulheres idosas. A mortalidade cardiovascular nas mulheres brasileiras é uma das mais elevadas do mundo ocidental. Os fatores de risco para doença cardiovascular mais conhecidos são tabagismo, hipercolesterolemia, hipertensão arterial e diabetes mellitus. Esses fatores, tidos como primários, podem ser conseqüência de fatores de risco primordiais como pode ser o caso do hipotireoidismo subclínico. A detecção precoce de doenças da tireóide em mulheres com mais de 50 anos pode ser uma opção custo-efetiva na prevenção das doenças cardiovasculares nas mulheres brasileiras. |
| وصف الملف: | text/html |
| تدمد: | 1516-3180 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0eec91b848a2e0a7417287cf97abdbTest https://doi.org/10.1590/s1516-31802002000500005Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fd0eec91b848a2e0a7417287cf97abdb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15163180 |
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