دورية أكاديمية
Notch1 Functions as a Tumor Suppressor in a Model of K-ras–Induced Pancreatic Ductal Adenocarcinoma
| العنوان: | Notch1 Functions as a Tumor Suppressor in a Model of K-ras–Induced Pancreatic Ductal Adenocarcinoma |
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| المؤلفون: | Hanlon, Linda, Avila, Jacqueline L, Demarest, Renée M, Troutman, Scott, Allen, Megan, Ratti, Francesca, Rustgi, Anil K, Stanger, Ben Z, Radtke, Fred, Adsay, Volkan, Long, Fenella, Capobianco, Anthony J, Kissil, Joseph L |
| المصدر: | Rowan-Virtua School of Osteopathic Medicine Faculty Scholarship |
| بيانات النشر: | Rowan Digital Works |
| سنة النشر: | 2010 |
| المجموعة: | Rowan University: Rowan Digital Works |
| مصطلحات موضوعية: | Animals, Carcinoma, Pancreatic Ductal, Disease Progression, Gene Deletion, Gene Expression Regulation, Neoplastic, Genes, Tumor Suppressor, ras, Mice, Transgenic, Pancreatic Neoplasms, Receptor, Notch1, Signal Transduction, beta Catenin, Medical Genetics, Medicine and Health Sciences, Molecular Biology, Neoplasms, Oncology |
| الوصف: | K-ras is the most commonly mutated oncogene in pancreatic cancer and its activation in murine models is sufficient to recapitulate the spectrum of lesions seen in human pancreatic ductal adenocarcinoma (PDAC). Recent studies suggest that Notch receptor signaling becomes reactivated in a subset of PDACs, leading to the hypothesis that Notch1 functions as an oncogene in this setting. To determine whether Notch1 is required for K-ras-induced tumorigenesis, we used a mouse model in which an oncogenic allele of K-ras is activated and Notch1 is deleted simultaneously in the pancreas. Unexpectedly, the loss of Notch1 in this model resulted in increased tumor incidence and progression, implying that Notch1 can function as a tumor suppressor gene in PDAC. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://rdw.rowan.edu/som_facpub/92Test; https://rdw.rowan.edu/context/som_facpub/article/1098/viewcontent/Demarest_Notch1_Functions_as_Tumor_Suppressor.pdfTest |
| DOI: | 10.1158/0008-5472.CAN-09-4645 |
| الإتاحة: | https://doi.org/10.1158/0008-5472.CAN-09-4645Test https://rdw.rowan.edu/som_facpub/92Test https://rdw.rowan.edu/context/som_facpub/article/1098/viewcontent/Demarest_Notch1_Functions_as_Tumor_Suppressor.pdfTest |
| رقم الانضمام: | edsbas.71B15019 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1158/0008-5472.CAN-09-4645 |
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