التفاصيل البيبلوغرافية
| العنوان: |
Interleukin-6 in synovial fluid is closely associated with chronic synovitis in rheumatoid arthritis. |
| المؤلفون: |
Sack, U., Kinne, R., Marx, T., Heppt, P., Bender, S., Emmrich, F. |
| المصدر: |
Rheumatology International; Jun1993, Vol. 13 Issue 2, p45-51, 7p |
| مستخلص: |
Interleukin-6 (IL-6) was detected at low levels in plasma [0.014±0.006 ng/ml (mean ± SEM] and in high amounts in synovial fluid [SF; 2.6±2.2 ng/ml (mean ± SEM)] of patients with rheumatoid arthritis. No correlation of IL-6 levels in plasma or SF with the ESR ( n=15) or with histological parameters of acute local synovitis ( n=10) was observed. In contrast, SF IL-6 was positively correlated with histological characteristics of chronic synovitis ( n=10; P≤0.01) and elevated plasma IgG concentrations ( n=15; P≤0.05). In vitro concentrations of IL-6 comparable to those detected in SF increased the production of both IgG and IgM by synovial membrane mononuclear cells. The present results contribute to the view that high local IL-6 concentrations in SF promote chronic synovitis in RA. [ABSTRACT FROM AUTHOR] |
|
Copyright of Rheumatology International is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
