المؤلفون: SOUZA, MARCIO, JANSEN, ANN, MARTINS, ALINE, RODRIGUES, LUIZ, REZENDE, NILTON

المصدر: Revista da Associação Médica Brasileira. December 2016 62(9)

مصطلحات موضوعية: neurofibromatosis type 1, nutritional status, anthropometry, body composition, adult

الوصف: SUMMARY Objective To evaluate the body composition and nutritional status of neurofibromatosis type 1 (NF1) adult patients. Method A cross-sectional study of 60 NF1 patients (29 men, 31 women) aged ≥ 18 years who were evaluated from September 2012 to September 2013 in a Neurofibromatosis Outpatient Reference Center. Patients underwent nutritional assessment including measurements of weight, stature, waist circumference (WC), upper-arm circumference (UAC), and skinfolds (biceps, triceps, subscapular, suprailiac). Body mass index (BMI), upper-arm total area (UATA), upper-arm muscle area (UAMA), upper-arm fat area (UAFA), body fat percentage (BFP), fat mass, fat-free mass, fat mass index, and fat-free mass index were also calculated. Results The mean age of the study population was 34.48±10.33 years. The prevalence of short stature was 28.3%. Low weight was present in 10% of the sample and 31.7% of patients had a BMI ≥ 25 kg/m2. Reduced UAMA (<5th percentile) was present in 43.3% and no difference was found in UAFA between the sexes. The BFP was considered high in 30% and 17 (28.3%) patients had a WC above the World Health Organization cutoffs. Conclusion In this study, NF1 patients had a high prevalence of underweight, short stature, and reduced UAMA, with no difference between the sexes. Reduced UAMA was more prevalent in underweight patients; however, this was also observed in the normal and overweight patients. Further studies should investigate the distribution of body tissues in NF1 patients, including differences between men and women, and the influence of diet and nutrition on clinical features in NF1.

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الوصول الحر: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016000900831Test

المؤلفون: Alexandra Corrêa Gervazoni Balbuena de Lima, Mariana Fiuza Gonçalves, Ester Vasconcelos Rocha, Luciana Bartolmei Orru D’Ávila, André Neves Mascarenhas

المصدر: Revista da Associação Médica Brasileira v.67 n.4 2021
Revista da Associação Médica Brasileira
Associação Médica Brasileira (AMB)
instacron:AMB
Revista da Associação Médica Brasileira, Volume: 67, Issue: 4, Pages: 505-510, Published: 06 SEP 2021
Revista da Associação Médica Brasileira, Vol 67, Iss 4, Pp 505-510 (2021)

مصطلحات موضوعية: Adult, Male, Medicine (General), medicine.medical_specialty, Cross-sectional study, Population, Young Adult, R5-920, Risk Factors, Diabetes mellitus, Internal medicine, medicine.artery, medicine, Humans, Ankle Brachial Index, Prospective Studies, cardiovascular diseases, Brachial artery, education, Prospective cohort study, Vascular calcification, education.field_of_study, Type 1 diabetes, business.industry, Diabetes mellitus, type 1, General Medicine, Atherosclerosis, medicine.disease, Cross-Sectional Studies, Diabetes Mellitus, Type 1, medicine.anatomical_structure, Blood pressure, Ankle-brachial index, cardiovascular system, Cardiology, Female, Ankle, business

الوصف: SUMMARY OBJECTIVE: To assess the prevalence of altered ankle-brachial index (1.3) in patients with type 1 diabetes and to compare it with the presence of subclinical atherosclerosis by carotid ultrasound. METHODS: Prospective, cross-sectional study in which 45 adults with type 1 diabetes were evaluated (age 34±10 years, 46.7% men). The data collected included anamnesis, clinical evaluation, calculation of the ankle-brachial index (relationship between systolic blood pressure in the ankle and brachial artery), and performance of carotid ultrasound. RESULTS: Thirty-two patients had ankle-brachial index >1.3 (66.7%) and no patient had ankle-brachial index 35 years and ankle-brachial index >1.4 showed a good correlation with atherosclerosis (r=0.49, p=0.021; r=0.56, p=0.008, respectively). A model associating age >35 years and ankle-brachial index >1.4 showed an excellent relationship with atherosclerosis (r=0.59, p=0.004). CONCLUSIONS: Our study showed that vascular calcification (ankle-brachial index >1.4) was frequent in this population with type 1 diabetes and associated with subclinical atherosclerosis. A model combining ankle-brachial index >1.4 and age >35 years showed an excellent correlation with atherosclerosis and can assist in clinical suspicion and optimize the request for additional tests.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da4745110bac01afa0936e36236a0cfTest
https://doi.org/10.1590/1806-9282.20200695Test

المؤلفون: Luís Costa Matos, João Olivério, Mónica Teixeira, Sofia Costa Martins, Gabriela Venade, João Machado, Joana Silva Marques

المصدر: Revista da Associação Médica Brasileira, Vol 65, Iss 12, Pp 1434-1437 (2020)
Revista da Associação Médica Brasileira, Volume: 65, Issue: 12, Pages: 1434-1437, Published: 24 JAN 2020

مصطلحات موضوعية: Adult, medicine.medical_specialty, Medicine (General), endocrine system diseases, Fludrocortisone, 030204 cardiovascular system & hematology, Hypoglycemia, Gastroenterology, Doenças da glândula tireoide, 03 medical and health sciences, Poliendocrinopatias autoimunes, Rare Diseases, 0302 clinical medicine, R5-920, Addison Disease, Internal medicine, medicine, Humans, Doença de Addison, 030212 general & internal medicine, Polyendocrinopathies, Autoimmune, Autoimmune disease, Type 1 diabetes, business.industry, Type 2 Diabetes Mellitus, General Medicine, medicine.disease, Thyroid Diseases, Graves Disease, Early Diagnosis, Treatment Outcome, Diabetes Mellitus, Type 1, Diabetes mellitus tipo 1, Addison's disease, Prednisolone, Autoimmune Polyglandular Syndrome Type 2, Female, business, Addison’s Disease, medicine.drug

الوصف: SUMMARY Autoimmune polyglandular syndrome type 2 (APS 2) is defined by the presence of Addison’s disease (AD) associated with autoimmune thyroid disease and/or Type 1 diabetes mellitus (T1DM). It is a rare disease, affecting about 1.4-2 cases/100,000 inhabitants. Its less frequent clinical presentation is the combination of AD, Graves‘ disease, and T1DM. We present the case of a 42-year-old woman with a history of total thyroidectomy due to Graves’ disease, type 2 diabetes mellitus, and hypertension, who sought the ED due to asthenia, dizziness, nausea, and vomiting. She reported having stopped antihypertensive therapy due to hypotension and presented a glycemic record with frequent hypoglycemia. On physical examination, she had cutaneous hyperpigmentation. She had no leukocytosis, anemia, hypoglycemia, hyponatremia or hyperkalemia, and a negative PCR. Serum cortisol

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248afd7af3b11b47970f8e068dc8af8fTest
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019001201434&tlng=enTest

المؤلفون: Jingjing Jiang, Shanshan Gao, Yang Zhang

المصدر: Revista da Associação Médica Brasileira, Vol 65, Iss 9, Pp 1144-1150 (2019)

مصطلحات موضوعية: Adult, Medicine (General), medicine.medical_specialty, medicine.medical_treatment, media_common.quotation_subject, Clomiphene, Endometrium, Young Adult, 03 medical and health sciences, Follicle, R5-920, 0302 clinical medicine, Ovarian Follicle, Ovulation Induction, Internal medicine, Follicular phase, medicine, Humans, Hypoglycemic Agents, Ovulation, Polycystic ovary syndrome, media_common, 030219 obstetrics & reproductive medicine, business.industry, Therapeutic effect, Fertility Agents, Female, General Medicine, Polycystic ovary, Metformin, Pregnancy rate, Endocrinology, Gene Expression Regulation, 030220 oncology & carcinogenesis, Cervix Mucus, Drug Therapy, Combination, Female, Ovulation induction, Sterol Regulatory Element Binding Protein 1, business, medicine.drug

الوصف: SUMMARY OBJECTIVE In view of the high incidence of polycystic ovary syndrome (PCOS) and the unsatisfactory therapeutic effects of dimethyldiguanide or clomifene citrate alone, our study aimed to investigate the therapeutic effects of dimethyldiguanide combined with clomifene citrate in the treatment of PCOS. METHODS A total of 79 patients with POCS and 35 healthy females were included, and endometrial biopsies were obtained. The sterol regulatory element-binding protein-1 (SREBP1) expression in endometrial tissues was detected by qRT-PCR. POC patients were randomly divided into group A (n=40) and group B (n=39). Patients in group A were treated with dimethyldiguanide combined with clomifene citrate, while patients in group B were treated with clomifene citrate alone. The number of mature follicles and cervical mucus score, follicular development rate and single follicle ovulation rate, cycle pregnancy rate, early miscarriage rate, ovulation rate, endometrial thickness, positive rate of three lines sign, follicle stimulating hormone level and luteinizing hormone level were compared between the two groups. RESULTS The expression level of SREBP1 was higher in PCOS patients than that in the healthy control. SREBP1 expression was inhibited after treatment, while the inhibitory effects of combined treatment were stronger than those of clomifene citrate alone. Compared with clomifene citrate alone, the combined treatment improved cervical mucus score, follicle development rate, single follicle ovulation rate, endometrial thickness, positive rate of three lines sign, and follicle-stimulating hormone level. CONCLUSION The therapeutic effect of combined treatment is better than clomifene citrate alone in the treatment of PCOS.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8a1a0489ff96d1a9649710dc4096d5Test
https://doi.org/10.1590/1806-9282.65.9.1144Test