Therapeutic effects of dimethyldiguanide combined with clomifene citrate in the treatment of polycystic ovary syndrome
| العنوان: | Therapeutic effects of dimethyldiguanide combined with clomifene citrate in the treatment of polycystic ovary syndrome |
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| المؤلفون: | Jingjing Jiang, Shanshan Gao, Yang Zhang |
| المصدر: | Revista da Associação Médica Brasileira, Vol 65, Iss 9, Pp 1144-1150 (2019) |
| بيانات النشر: | FapUNIFESP (SciELO), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Medicine (General), medicine.medical_specialty, medicine.medical_treatment, media_common.quotation_subject, Clomiphene, Endometrium, Young Adult, 03 medical and health sciences, Follicle, R5-920, 0302 clinical medicine, Ovarian Follicle, Ovulation Induction, Internal medicine, Follicular phase, medicine, Humans, Hypoglycemic Agents, Ovulation, Polycystic ovary syndrome, media_common, 030219 obstetrics & reproductive medicine, business.industry, Therapeutic effect, Fertility Agents, Female, General Medicine, Polycystic ovary, Metformin, Pregnancy rate, Endocrinology, Gene Expression Regulation, 030220 oncology & carcinogenesis, Cervix Mucus, Drug Therapy, Combination, Female, Ovulation induction, Sterol Regulatory Element Binding Protein 1, business, medicine.drug |
| الوصف: | SUMMARY OBJECTIVE In view of the high incidence of polycystic ovary syndrome (PCOS) and the unsatisfactory therapeutic effects of dimethyldiguanide or clomifene citrate alone, our study aimed to investigate the therapeutic effects of dimethyldiguanide combined with clomifene citrate in the treatment of PCOS. METHODS A total of 79 patients with POCS and 35 healthy females were included, and endometrial biopsies were obtained. The sterol regulatory element-binding protein-1 (SREBP1) expression in endometrial tissues was detected by qRT-PCR. POC patients were randomly divided into group A (n=40) and group B (n=39). Patients in group A were treated with dimethyldiguanide combined with clomifene citrate, while patients in group B were treated with clomifene citrate alone. The number of mature follicles and cervical mucus score, follicular development rate and single follicle ovulation rate, cycle pregnancy rate, early miscarriage rate, ovulation rate, endometrial thickness, positive rate of three lines sign, follicle stimulating hormone level and luteinizing hormone level were compared between the two groups. RESULTS The expression level of SREBP1 was higher in PCOS patients than that in the healthy control. SREBP1 expression was inhibited after treatment, while the inhibitory effects of combined treatment were stronger than those of clomifene citrate alone. Compared with clomifene citrate alone, the combined treatment improved cervical mucus score, follicle development rate, single follicle ovulation rate, endometrial thickness, positive rate of three lines sign, and follicle-stimulating hormone level. CONCLUSION The therapeutic effect of combined treatment is better than clomifene citrate alone in the treatment of PCOS. |
| تدمد: | 1806-9282 0104-4230 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8a1a0489ff96d1a9649710dc4096d5Test https://doi.org/10.1590/1806-9282.65.9.1144Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5a8a1a0489ff96d1a9649710dc4096d5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18069282 01044230 |
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