Proinflammatory and anti-inflammatory cytokines in febrile seizures and epilepsy: systematic review and meta-analysis
| العنوان: | Proinflammatory and anti-inflammatory cytokines in febrile seizures and epilepsy: systematic review and meta-analysis |
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| المؤلفون: | Alipasha Meysamie, Maryam Gharedaghi, Amene Saghazadeh, Nima Rezaei, Sebastian Bauer |
| المصدر: | Reviews in the Neurosciences. 25 |
| بيانات النشر: | Walter de Gruyter GmbH, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | medicine.medical_specialty, Epilepsy, Neurology, Interleukin-6, business.industry, General Neuroscience, medicine.medical_treatment, Interleukin-1beta, Interleukin, medicine.disease, Polymorphism, Single Nucleotide, Seizures, Febrile, Proinflammatory cytokine, Cytokine, Polymorphism (computer science), Interleukin-1alpha, Genotype, Immunology, medicine, Humans, Allele, business |
| الوصف: | Activation of proinflammatory and anti-inflammatory cytokines network seems to have a role in febrile seizures (FS). The present meta-analysis was aimed to pool the inconsistent data provided with case-control studies on the relationship of proinflammatory and anti-inflammatory cytokines and FS/epilepsy risk. The genotype interleukin (IL)-1α-889 1/1 (recessive model) was significantly correlated with increased risk of epilepsy (p=0.008) and FS/epilepsy (p=0.004). Patients with IL-1β-511 T/T homozygote were more susceptible to develop FS (p=0.036) but not epilepsy. Furthermore, the T/T genotype was totally associated with increased risk of FS/epilepsy (p=0.043). Although the recessive model was also confirmed for the Asian subgroup (FS and FS/epilepsy), we found a protective effect of C/C genotype toward developing FS in the Caucasian race (p=0.020). The second meta-analysis on cytokine levels showed a statistically higher serum level of IL-6 in patients with epilepsy compared to control subjects without epilepsy. The present meta-analysis showed that two alleles of proinflammatory cytokines (IL-1α-889 and IL-1β-511) in addition to the serum concentration of IL-6 were significantly associated with FS and epilepsy or both in various subgroup analyses. |
| تدمد: | 2191-0200 0334-1763 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d53bff2132c63473aa360834374ec1dTest https://doi.org/10.1515/revneuro-2013-0045Test |
| رقم الانضمام: | edsair.doi.dedup.....7d53bff2132c63473aa360834374ec1d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21910200 03341763 |
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