التفاصيل البيبلوغرافية
| العنوان: |
HYPERREFLECTIVE FOCI PRECEDE MACULAR NEOVASCULARIZATION FORMATION IN ANGIOID STREAKS. |
| المؤلفون: |
Arrigo, Alessandro, Antropoli, Alessio, Bianco, Lorenzo, Rosolia, Andrea, Vuturo, Alessia, Bandello, Francesco, Battaglia Parodi, Maurizio |
| المصدر: |
Retinal Cases & Brief Reports; Jul2023, Vol. 17 Issue 4, p392-396, 5p |
| مستخلص: |
In this study, we described multimodal imaging findings occurring before the onset of macular neovascularization in angioid streaks. Our imaging findings suggest that intraretinal hyperreflective foci concentration and migration may represent the early alterations preceding macular neovascularization complication. Purpose: To describe the steps leading to the development and progression of macular neovascularization (MNV) in angioid streaks. Methods: The study was designed as retrospective, longitudinal case series. Patients with angioid streaks were investigated by means of multimodal imaging, including fundus autofluorescence and structural optical coherence tomography. Main outcome measures were hyperreflective foci and MNV progression steps. Results: Overall, 40 eyes (20 patients) affected by angioid streaks were evaluated. Over the follow-up, five eyes of five patients developed MNV. The mean follow-up was of 1.6 years. The mean number of anti–vascular endothelial growth factor injections was 4.35 ± 1.4. Mean best-corrected visual acuity was 0.53 ± 0.38 LogMAR at the MNV onset, improving to 0.42 ± 0.40 LogMAR at the end of the follow-up (P > 0.05). Intraretinal hyperreflective foci onset and coalescence represented the first alterations occurring before the onset of the MNV. Anti–vascular endothelial growth factor treatment was associated with exudation relapsing and remitting, with still present intraretinal hyperreflective foci and pigment accumulation. The longitudinal analysis of our cohort of eyes outlined the event timeline: 1.2 months to find concentrated hyperreflective foci, 4.5 months to observe pigment organization through the outer nuclear layer, and 1.5 years to detect MNV. Conclusion: Hyperreflective foci formation, concentration, and migration represent early alterations occurring before the onset of the MNV in angioid streaks. [ABSTRACT FROM AUTHOR] |
|
Copyright of Retinal Cases & Brief Reports is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Supplemental Index |
