التفاصيل البيبلوغرافية
| العنوان: |
Impact of Spontaneous Breathing Trial on Work of Breathing Indices Derived From Esophageal Pressure, Electrical Activity of the Diaphragm, and Oxygen Consumption in Children. |
| المؤلفون: |
Mortamet, Guillaume, Nardi, Nicolas, Groleau, Véronique, Essouri, Sandrine, Fauroux, Brigitte, Jouvet, Philippe, Emeriaud, Guillaume |
| المصدر: |
Respiratory Care; May2019, Vol. 64 Issue 5, p509-518, 10p, 2 Charts, 2 Graphs |
| مصطلحات موضوعية: |
DIAPHRAGM physiology, ESOPHAGEAL physiology, RESPIRATORY muscle physiology, ANALYSIS of variance, ARTIFICIAL respiration, CALORIMETRY, CHI-squared test, STATISTICAL correlation, CRITICALLY ill, FISHER exact test, INTENSIVE care units, LONGITUDINAL method, PATIENTS, PEDIATRICS, RESEARCH funding, RESPIRATION, T-test (Statistics), MECHANICAL ventilators, RELATIVE medical risk, PRE-tests & post-tests, CONTINUING education units, REPEATED measures design, OXYGEN consumption, DATA analysis software, DESCRIPTIVE statistics, POSITIVE end-expiratory pressure, MANN Whitney U Test, CHILDREN |
| مصطلحات جغرافية: |
CANADA |
| مستخلص: |
BACKGROUND: The present study aimed to characterize the behavior of 3 components of respiratory muscle function during mechanical ventilation weaning in children to better understand the respective impact of a spontaneous breathing trial on ventilatory mechanical action (esophageal pressure [Pes], ventilatory demand (electrical activity of the diaphragm [EAdi]), and oxygen consumption. METHODS: This was a prospective single-center study. All children > 1 months and <18 y old who were intubated and on mechanical ventilation, and who were hospitalized in the pediatric ICU were eligible. Subjects considered as ready to extubate were included. Simultaneous recordings of oxygen consumption, Pes, and EAdi were performed during 3 steps: before, during, and after the spontaneous breathing test. RESULTS: Twenty subjects (median age, 5.5 mo) were included. Half of them were admitted for a respiratory cause. The increase in Pes swings and esophageal pressure-time product during the spontaneous breathing trial was not significant (P = .33 and P = .75, respectively), and a similar trend was observed with peak EAdi (P = .06). Oxygen consumption obtained by indirect calorimetry was stable in the 3 conditions (P = .98). CONCLUSIONS: In these children who were critically ill, a spontaneous breathing trial induced a moderate and nonsignificant increase in work of breathing, as reflected by the respiratory drive with EAdi and respiratory mechanics with Pes. However, indirect calorimetry did not seem to be a sensitive tool to assess respiratory muscle function during the weaning phase in children who were on mechanical ventilation, especially when work of breathing was slightly increased. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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