Development of a risk-oriented algorithm for the combined use of hemostatics and anticoagulants to prevent thrombosis and bleeding cases after total arthroplasty of knee or hip joints
| العنوان: | Development of a risk-oriented algorithm for the combined use of hemostatics and anticoagulants to prevent thrombosis and bleeding cases after total arthroplasty of knee or hip joints |
|---|---|
| المؤلفون: | Elena V. Gantsgorn, Lilia S. Golovko, Nataliya V. Sukhorukova, Andrey V. Safronenko, Andrey V. Kapliev |
| المصدر: | Research Results in Pharmacology, Vol 7, Iss 1, Pp 65-74 (2021) Research Results in Pharmacology 7(1): 65-74 |
| بيانات النشر: | Belgorod National Research University, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | anticoagulants, medicine.medical_specialty, coagulogram, medicine.medical_treatment, Combined use, RM1-950, 03 medical and health sciences, 0302 clinical medicine, hemostatics, medicine, Pharmacology (medical), thrombosis, 030203 arthritis & rheumatology, Pharmacology, 030222 orthopedics, business.industry, time interval, bleeding, medicine.disease, Arthroplasty, Thrombosis, Comorbidity, Hemostatics, Surgery, comorbidity, endoprosthetics, Therapeutics. Pharmacology, business |
| الوصف: | Introduction: The goal of our study was to develop a risk-oriented algorithm for the combined use of hemostatics and anticoagulants in patients after total arthroplasty of the knee or hip joints to reduce the risk of thrombohemorrhagic complications. Materials and methods: We performed a retrospective study (n=253). In group (Gr.) 1, the time interval (TI) between the administration of hemostatic and anticoagulant prophylaxis was ≤17 hours (n=145; 57.31%), and in Gr. 2 – 18-24 hours (n=108; 42.68%). We analyzed the influence of different factors on the development of thrombosis and bleeding cases after the operation. Results and discussion: Thrombohemorrhagic complications were observed in 27 (10.67%) patients. Thrombosis in Gr. 1 was associated with the use of tranexamic acid, and were recorded 2.2 times more often than in Gr. 2 (p75 years, for women – an initially low level of international normalized ratio, and activated partial thromboplastin time (APTT) (p75 years, among men and women – an increased preoperative level of APTT, for women – a decreased level of fibrinogen and platelets (p |
| وصف الملف: | text/html |
| تدمد: | 2658-381X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377f7b36dd69fe027ba7ad501b2d87b4Test https://doi.org/10.3897/rrpharmacology.7.65708Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....377f7b36dd69fe027ba7ad501b2d87b4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2658381X |
|---|