دورية أكاديمية
Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses
| العنوان: | Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses |
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| المؤلفون: | Moody, M.A., Gao, F., Gurley, T.C., Amos, J.D., Kumar, A., Hora, B., Marshall, D.J., Whitesides, J.F., Xia, S.-M., Parks, R., Llyod, K.E., Hwang, K.-K., Lu, X., Bonsignori, M., Finzi, A., Vandergrift, N.A., Alam, S.M., Ferrari, G., Shen, X., Tomaras, G.D., Kamanga, G., Cohen, M.S., Sam, N.E., Kapiga, S., Grey, Elin S., Tumba, N.L., Morris, L., Zolla-Pazner, S., Gorny, M.K., Mascola, J.R., Hahn, B.H., Shaw, G.M., Sodroski, J.G., Liao, H.-X., Montefiori, D.C., Hraber, P.T., Korber, B.T., Haynes, B.F. |
| المصدر: | Research outputs 2014 to 2021 |
| بيانات النشر: | Edith Cowan University, Research Online, Perth, Western Australia |
| سنة النشر: | 2015 |
| المجموعة: | Edith Cowan University (ECU, Australia): Research Online |
| مصطلحات موضوعية: | CD4 antigen, immunoglobulin A2, immunoglobulin G1, neutralizing antibody, unclassified drug, v3 loop peptide, virus envelope protein, Article, B lymphocyte, binding site, epitope mapping, human, human cell, Human immunodeficiency virus 1, Human immunodeficiency virus 1 infection, in vivo study, memory cell, peripheral blood mononuclear cell, phenotype, phylogenetic tree, priority journal, protein binding, virus neutralization, virus resistance, virus strain, virus transmission, Immune System Diseases, Virus Diseases |
| الوصف: | The third variable (V3) loop and the CD4 binding site (CD4bs) of the HIV-1 envelope are frequently targeted by neutralizing antibodies (nAbs) in infected individuals. In chronic infection, HIV-1 escape mutants repopulate the plasma, and V3 and CD4bs nAbs emerge that can neutralize heterologous tier 1 easy-to-neutralize but not tier 2 difficult-to-neutralize HIV-1 isolates. However, neutralization sensitivity of autologous plasma viruses to this type of nAb response has not been studied. We describe the development and evolution in vivo of antibodies distinguished by their target specificity for V3 and CD4bs epitopes on autologous tier 2 viruses but not on heterologous tier 2 viruses. A surprisingly high fraction of autologous circulating viruses was sensitive to these antibodies. These findings demonstrate a role for V3 and CD4bs antibodies in constraining the native envelope trimer in vivo to a neutralization-resistant phenotype, explaining why HIV-1 transmission generally occurs by tier 2 neutralization-resistant viruses. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://ro.ecu.edu.au/ecuworkspost2013/1155Test; https://doi.org/10.1016/j.chom.2015.08.006Test |
| DOI: | 10.1016/j.chom.2015.08.006 |
| الإتاحة: | https://doi.org/10.1016/j.chom.2015.08.006Test https://ro.ecu.edu.au/ecuworkspost2013/1155Test |
| حقوق: | free_to_read |
| رقم الانضمام: | edsbas.8BB391B8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.chom.2015.08.006 |
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