Design, synthesis, in silico ADME/T profiling of pseudo-pyrimidine derivatives and anticancer activity evaluation
| العنوان: | Design, synthesis, in silico ADME/T profiling of pseudo-pyrimidine derivatives and anticancer activity evaluation |
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| المؤلفون: | Dolly Sharma, Vinit Kumar, Reshma Rani |
| المصدر: | Research Journal of Chemistry and Environment. 26:30-37 |
| بيانات النشر: | World Researchers Associations, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Renewable Energy, Sustainability and the Environment, General Chemical Engineering, General Earth and Planetary Sciences, General Chemistry, General Agricultural and Biological Sciences, Biochemistry, General Environmental Science |
| الوصف: | Pyrimidines are aromatic heterocyclic nitrogenous bases predominantly present as integral building blocks of DNA and RNA. The alternating single and double bonds connecting the C and N atoms in these 6-membered heterocyclic rings confer them to resonance, aromaticity and exceptional stability. The prevalence of pyrimidine derivatives in nucleic acids, vitamins, amino acids, antibiotics, alkaloids and several reported bioactive compounds promoted investigation of their novel biological roles which eventually demonstrated a plethora of medicinal advantages of the pyrimidine scaffold by virtue of its synthetic versatility. In this research work, we aim to explore the anticancer activity of various substituent derivatives of thiopyrimidines and present them as a novel, potential anti-cancer strategy. A series of novel disubstituted derivatives of thiopyrimidine were designed and synthesized [Fig. 1]. Further, the promising results of in vitro biological assays conclusively indicate their anti-cancer potential. |
| تدمد: | 2278-4527 0972-0626 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::298ba4e8218a4b56d37a832ad0fecab4Test https://doi.org/10.25303/2608rjce30037Test |
| رقم الانضمام: | edsair.doi...........298ba4e8218a4b56d37a832ad0fecab4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22784527 09720626 |
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