التفاصيل البيبلوغرافية
| العنوان: |
Immunohistochemical expression of MMP-14 and MMP-2, and MMP-2 activity during human ovarian follicular development. |
| المؤلفون: |
Vos, Maria Caroline, van der Wurff, Anneke A. M., Last, Jessie T. J., de Boed, Ella A. M., Smeenk, Jesper M. J., van Kuppevelt, Toin H., Massuger, Leon F. A. G. |
| المصدر: |
Reproductive Biology & Endocrinology; 2014, Vol. 12 Issue 1, p1-25, 25p |
| مصطلحات موضوعية: |
OVARIAN follicle, IMMUNOHISTOCHEMISTRY, CORPUS luteum, LUTEINIZING hormone releasing hormone, GONADOTROPIN |
| مستخلص: |
Background The aim of this study was to investigate the presence of MMP-14 and MMP-2 during human ovarian follicular development using immunohistochemistry, and the activity of MMP-2 in follicular fluid using zymography. Methods Ovarian tissue collected from the archives of the Department of Pathology was examined and medical records and histopathology were reviewed. Follicular fluids were collected at the IVF-department and analyzed using zymography. Results MMP-14 and MMP-2 were increasingly found in the growing follicles and MMP-2 was highly expressed in the corpus luteum. Pro-MMP-2 was present in follicular fluid of IVFpatients. Conclusions The presence of MMP-14 and MMP-2 during human ovarian follicular development from the primordial follicle to the tertiary follicle and corpus luteum is confirmed, as was indicated by earlier animal studies following stimulation with gonadotrophins. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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