التفاصيل البيبلوغرافية
| العنوان: |
Caffeic Acid Phenethyl Ester Protects Kidneys against Acetylsalicylic Acid Toxicity in Rats. |
| المؤلفون: |
Bozkurt, Yasar, Bozkurt, Mehtap, Turkçu, Gul, Sancaktutar, Ahmet Ali, Soylemez, Haluk, Penbegul, Necmettin, Atar, Murat, Bodakcı, Mehmet Nuri, Hatipoglu, Namık Kemal, Yuksel, Hatice, Kıbrıslı, Erkan, Yavuz, Celal |
| المصدر: |
Renal Failure; 2012, Vol. 34 Issue 9, p1150-1155, 6p, 1 Color Photograph, 1 Chart |
| مصطلحات موضوعية: |
CAFFEIC acid, ASPIRIN, LABORATORY rats, NEPHROTOXICOLOGY, PHARMACODYNAMICS, KIDNEY disease prevention, ESTERS, HISTOPATHOLOGY, THERAPEUTICS |
| مستخلص: |
Aim: The aim of this study was to investigate the protective effect of caffeic acid phenethyl ester (CAPE) on acetylsalicylic acid (ASA)-induced renal damage in rats. Materials and methods: A total of 40 rats were randomly divided into five groups, with eight rats in each group-group 1: control, not receiving any medication; group 2: ASA (50 mg/kg/day); group 3: ASA (50 mg/kg/day) + CAPE (20 μg/kg/day); group 4: ASA (100 mg/kg/day); and group 5: ASA (100 mg/kg/day) + CAPE (20 μg/kg/day). ASA and CAPE were given via orogastric gavage for 5 days. The total oxidant status (TOS), total antioxidant capacity (TAC), and paraoxonase-1 (PON-1) activity of the blood samples and kidney tissues were determined. Histopathological examinations of the kidneys were performed using light microscopic methods. Results: The TOS level in the serum of rats and kidney tissues given ASA (groups 2 and 4) significantly increased, but the levels of TAC and PON-1 in these tissues significantly decreased in group 4 when compared with the control rats ( p < 0.05). The levels of TAC and PON-1 in the kidney tissues increased and the levels of TOS decreased in the CAPE treatment groups (groups 3 and 5) when compared with the rats in the no CAPE treatment groups (groups 2 and 4). The PON-1, TAC, and TOS values reverted to normal levels in group 5 when compared to group 4 ( p < 0.05). These results were supported by histopathological observation. Conclusion: Oxidative stress plays an important role in ASA-induced nephrotoxicity, and CAPE may protect against ASA-induced nephrotoxicity in rats. [ABSTRACT FROM AUTHOR] |
|
Copyright of Renal Failure is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
