Aged kidneys are refractory to ischemic postconditioning in a rat model
| العنوان: | Aged kidneys are refractory to ischemic postconditioning in a rat model |
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| المؤلفون: | Bianzhi Xing, Xiuheng Liu, Zhiyuan Chen, Xiaodong Weng, Lei Wang, Hui Chen |
| المصدر: | Renal Failure. 36:1575-1580 |
| بيانات النشر: | Informa UK Limited, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Aging, medicine.medical_specialty, Ischemia, Apoptosis, Kidney, Critical Care and Intensive Care Medicine, medicine.disease_cause, Random Allocation, chemistry.chemical_compound, In vivo, Internal medicine, medicine, Animals, Treatment Failure, Rats, Wistar, Ischemic Postconditioning, Creatinine, Renal ischemia, business.industry, General Medicine, Blood flow, Acute Kidney Injury, medicine.disease, Disease Models, Animal, Oxidative Stress, Endocrinology, medicine.anatomical_structure, chemistry, Nephrology, Reperfusion Injury, Anesthesia, business, Oxidative stress |
| الوصف: | Ischemic postconditioning (IPoC) is defined as a series of intermittent interruptions of blood flow in the early phase of reperfusion that mechanically alters the hydrodynamics of reperfusion and it attenuates renal damage after ischemia/reperfusion (I/R) injury in vivo. But all of these data had been obtained in adult populations and whether this protection was maintained in aging kidneys was unknown. The objective of this study was to establish whether the efficacy of IPoC is maintained in aging kidneys.The aged (24-month-old) and young (3-month-old) Wistar rats were used. Rats were subjected to 45 min of renal ischemia, both with and without treatment with IPoC. Serum urea nitrogen and creatinine levels, histological examination and apoptosis were assessed at 24 h. Oxidative stress was evaluated and apoptosis-related molecules were studied by Western blotting.In young rat kidneys, IPoC significantly attenuated the renal dysfunction and cell apoptosis induced by I/R. In contrast, IPoC failed to limit renal dysfunction, possibly a consequence of increased apoptosis in aged rat kidneys.Our data indicated that IPoC was ineffective in aged rat kidneys. These findings may have major implications in that severe apoptosis in aged kidneys might be refractory to anti-apoptotic effect by IPoC. |
| تدمد: | 1525-6049 0886-022X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c849f1e14f1434d6de3fa1bbf515ca7aTest https://doi.org/10.3109/0886022x.2014.949769Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c849f1e14f1434d6de3fa1bbf515ca7a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15256049 0886022X |
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