دورية أكاديمية
Biomarker and transcriptomics profiles of serum selenium concentrations in patients with heart failure are associated with immunoregulatory processes
| العنوان: | Biomarker and transcriptomics profiles of serum selenium concentrations in patients with heart failure are associated with immunoregulatory processes |
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| المؤلفون: | Ali A. Al-Mubarak, George Markousis Mavrogenis, Xuanxuan Guo, Marco De Bruyn, Mintu Nath, Simon P.R. Romaine, Niels Grote Beverborg, Karla Arevalo Gomez, Sietske N. Zijlstra, Dirk J. van Veldhuisen, Nilesh J. Samani, Adriaan A. Voors, Peter van der Meer, Nils Bomer |
| المصدر: | Redox Biology, Vol 70, Iss , Pp 103046- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Selenium, Heart failure, Inflammation, Micronutrients, T cells, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Background: Low selenium concentrations are associated with worse outcomes in heart failure (HF). However, the underlying pathophysiologic mechanisms remain incompletely understood. Therefore, we aimed to contrast serum selenium concentrations to blood biomarker and transcriptomic profiles in patients with HF. Methods: Circulating biomarkers, whole blood transcriptomics and serum selenium measurements in a cohort of 2328 patients with HF were utilized. Penalized linear regression and gene expression analysis were used to assess biomarker and transcriptomics profiles, respectively. As a proof-of-principle, potential causal effects of selenium on excreted cytokines concentrations were investigated using human peripheral blood mononuclear cells (PBMCs). Results: Mean selenium levels were 60.6 μg/L in Q1 and 122.0 μg/L in Q4. From 356 biomarkers and 20 clinical features, the penalized linear regression model yielded 44 variables with |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2213-2317 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2213231724000223Test; https://doaj.org/toc/2213-2317Test |
| DOI: | 10.1016/j.redox.2024.103046 |
| الوصول الحر: | https://doaj.org/article/0c28f97bfc2e48b8b3a335635dabf246Test |
| رقم الانضمام: | edsdoj.0c28f97bfc2e48b8b3a335635dabf246 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22132317 |
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| DOI: | 10.1016/j.redox.2024.103046 |