التفاصيل البيبلوغرافية
| العنوان: |
Antineoplastics: Haemophagocytic lymphohistiocytosis. |
| المصدر: |
Reactions Weekly; 3/30/2024, Vol. 2001 Issue 1, p35-35, 1p |
| مصطلحات موضوعية: |
HEMOPHAGOCYTIC lymphohistiocytosis, ANTINEOPLASTIC agents, FEVER, CONGENITAL disorders, DRUG side effects, LACTATE dehydrogenase |
| مستخلص: |
A 63-year-old man developed haemophagocytic lymphohistiocytosis (HLH) while being treated for metastatic melanoma with binimetinib, dabrafenib, encorafenib, and trametinib. After three months of treatment, he achieved a complete response, but five months later, he developed symptoms including fever, splenomegaly, and hepatic cytolysis. Laboratory tests and imaging confirmed a diagnosis of drug-induced HLH. The medications were discontinued, and HLH resolved, but when the man started a second-line therapy with encorafenib and binimetinib, HLH symptoms recurred. Treatment with corticosteroids was initiated, and HLH eventually resolved. [Extracted from the article] |
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| قاعدة البيانات: |
Complementary Index |
