التفاصيل البيبلوغرافية
| العنوان: |
Radiation therapy as a bridging and salvage strategy in patients with relapsed or refractory multiple myeloma undergoing BCMA-targeted CAR T-cell therapy. |
| المؤلفون: |
Ababneh, Hazim S.1 (AUTHOR), Yee, Andrew J.2 (AUTHOR), Raje, Noopur S.2 (AUTHOR), Martin, Sidney1 (AUTHOR), Frigault, Matthew J.2 (AUTHOR), Ng, Andrea K.3 (AUTHOR), Patel, Chirayu G.1 (AUTHOR) cpatel@mgh.harvard.edu |
| المصدر: |
Radiotherapy & Oncology. Dec2023, Vol. 189, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*MULTIPLE myeloma, *T cells, *RADIOTHERAPY, *SALVAGE therapy, *CHIMERIC antigen receptors |
| مستخلص: |
Radiation therapy (RT) may play an important role prior to and following BCMA-targeted CAR T-cell therapy in multiple myeloma (MM). We report a series of 13 patients: 5 patients received bridging RT pre-CAR T, 4 patients received salvage RT post-CAR T failure, and 4 patients received both. There was no worsening of CAR-T- or RT-related toxicities. The RT in-field local control rate was 100%, with a median follow-up after each RT course of 7.3 months. RT as a bridging and salvage strategy is safe, feasible, and offers excellent local control in MM patients treated with CAR T-cell therapy. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
