Long-term radiological and histological outcomes following selective internal radiation therapy to liver metastases from breast cancer
| العنوان: | Long-term radiological and histological outcomes following selective internal radiation therapy to liver metastases from breast cancer |
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| المؤلفون: | Fergus V. Gleeson, Karin H. Herbschleb, Mark R. Middleton, Constantin C. Coussios, Leticia Campo, Helen Winter, Philip Boardman, Ricky A. Sharma, Feng Wu, Paul C. Lyon, Robert D. Goldin, Robert Carlisle |
| المصدر: | Radiology Case Reports, Vol 13, Iss 6, Pp 1259-1266 (2018) Radiology Case Reports, 13, 6, pp. 1259-1266 Radiology Case Reports, 13, 1259-1266 |
| بيانات النشر: | Elsevier, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Oncology, lcsh:Medical physics. Medical radiology. Nuclear medicine, medicine.medical_specialty, Liver tumor, Colorectal cancer, business.industry, lcsh:R895-920, Selective internal radiation therapy, Bone metastasis, Breast Adenocarcinoma, medicine.disease, 030218 nuclear medicine & medical imaging, Metastasis, 03 medical and health sciences, Cancer development and immune defence Radboud Institute for Health Sciences [Radboudumc 2], 0302 clinical medicine, Breast cancer, Refractory, 030220 oncology & carcinogenesis, Internal medicine, medicine, Radiology, Nuclear Medicine and imaging, business |
| الوصف: | Liver metastasis from breast cancer is associated with poor prognosis and is a major cause of early morbidity and mortality. When liver resection is not feasible, minimally invasive directed therapies are considered to attempt to prolong survival. Selective internal radiation therapy (SIRT) with yttrium-90 microspheres is a liver-directed therapy that can improve local control of liver metastases from colorectal cancer. We present a case of a patient with a ductal breast adenocarcinoma, who developed liver and bone metastasis despite extensive treatment with systemic chemotherapies. Following SIRT to the liver, after an initial response, the patient ultimately progressed in the liver after 7 months. Liver tumor histology obtained 20 months after the SIRT intervention demonstrated the presence of the resin microspheres in situ. This case report demonstrates the long-term control that may be achieved with SIRT to treat liver metastases from breast cancer that is refractory to previous chemotherapies, and the presence of microspheres in situ long-term. Keywords: Selective internal radiation therapy, SIRT, Transarterial radioembolization, Liver-directed therapy |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1930-0433 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f79013ae7b74c574d8fd2ae3058f9a5Test http://www.sciencedirect.com/science/article/pii/S1930043318302206Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0f79013ae7b74c574d8fd2ae3058f9a5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19300433 |
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