A population-based study of the effectiveness of stereotactic ablative radiotherapy versus conventional fractionated radiotherapy for clinical stage I non-small cell lung cancer patients
| العنوان: | A population-based study of the effectiveness of stereotactic ablative radiotherapy versus conventional fractionated radiotherapy for clinical stage I non-small cell lung cancer patients |
|---|---|
| المؤلفون: | Hsin Yuan Fang, Su Tso Yang, Ji An Liang, Chih Yen Tu, Te Chun Hsia, Chia Chin Li, Chun Ru Chien |
| المصدر: | Radiology and Oncology, Vol 52, Iss 2, Pp 181-188 (2017) Radiology and Oncology |
| بيانات النشر: | Walter de Gruyter GmbH, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, stereotactic ablative radiotherapy, medicine.medical_treatment, Population, R895-920, SABR volatility model, 030218 nuclear medicine & medical imaging, law.invention, Medical physics. Medical radiology. Nuclear medicine, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, conventional fractionated radiotherapy, law, Internal medicine, medicine, Radiology, Nuclear Medicine and imaging, education, non-small cell lung cancer, education.field_of_study, business.industry, Inverse probability weighting, Hazard ratio, Confidence interval, respiratory tract diseases, Radiation therapy, 030220 oncology & carcinogenesis, Propensity score matching, business, Research Article |
| الوصف: | Background Stereotactic ablative radiotherapy (SABR) is a promising option for non-operated early-stage non-small cell lung cancer (NSCLC) compared to conventional fractionated radiotherapy (CFRT). However, results from conclusive randomized controlled trials are not yet available. The aim of our study was to explore the effectiveness of SABR vs. CFRT for non-operated early-stage NSCLC. Patients and methods We used a comprehensive population-based database to identify clinical stage I non-operated NSCLC patients in Taiwan diagnosed from 2007 to 2013 who were treated with either SABR or CFRT. We used inverse probability weighting and the propensity score as the primary form of analysis to address the nonrandomization of treatment. In the supplementary analyses, we constructed subgroups based on propensity score matching to compare survival between patients treated with SABR vs. CFRT. Results We identified 238 patients in our primary analysis. A good balance of covariates was achieved using the propensity score weighting. Overall survival (OS) was not significantly different between those treated with SABR vs. CFRT (SABR vs. CFRT: probability weighting adjusted hazard ratio [HR] 0.586, 95% confidence interval 0.264–1.101, p = 0.102). However, SABR was significantly favored in supplementary analyses. Conclusions In this population-based propensity-score adjusted analysis, we found that OS was not significantly different between those treated with SABR vs. CFRT in the primary analysis, although significance was observed in the supplementary analyses. Our results should be interpreted with caution given the database (i.e., nonrandomized) approach used in our study. Overall, further studies are required to explore these issues. |
| تدمد: | 1581-3207 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358b259a4a143aecbf2cecef180b6149Test https://doi.org/10.1515/raon-2017-0058Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....358b259a4a143aecbf2cecef180b6149 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15813207 |
|---|