التفاصيل البيبلوغرافية
| العنوان: |
Prevalence of metastases within the hypothalamic-pituitary area in patients with brain metastases. |
| المؤلفون: |
Janssen, Stefan, Mehta, Preena, Bartscht, Tobias, Schmid, Sebastian M., Fahlbusch, Fabian B., Rades, Dirk |
| المصدر: |
Radiation Oncology; 8/27/2019, Vol. 14 Issue 1, pN.PAG-N.PAG, 1p |
| مصطلحات موضوعية: |
BRAIN metastasis, PITUITARY gland, METASTASIS, MAGNETIC resonance imaging, DISEASE prevalence |
| مستخلص: |
Aim: To quantify the prevalence of brain metastases involving the hypothalamic-pituitary (HT-P) area.Introduction: Cognitive impairment and fatigue are common side effects of whole brain irradiation (WBI) comprising the quality of life (QoL) for survivors. While the former is related to radiation-induced hippocampal injury, the latter could be secondary to hormonal disbalance as a consequence of radiation of the HT-P area. Thus, sparing both regions from higher irradiation doses could reduce these sequelae.Methods: T1 contrast medium enhanced magnetic resonance imaging (MRI) scans of 865 patients with brain metastases (4,280 metastases) were reviewed. HT-P area was individually contoured with a margin of 5 mm in order to evaluate the prevalence of brain metastases in this region.Results: Involvement of the hypothalamic region was found in 26 patients (involvement rate of 3% for patients and 1% for metastases), involvement of the pituitary gland in 9 patients (1% for patients and < 1% for metastases). Binary logistical regression analysis revealed the presence of > 10 brain metastases as the only factor associated with hypothalamic involvement while no distinct factor was associated with an involvement of the pituitary gland.Conclusion: The low prevalence of metastases within the HT-P area in patients with brain metastases calls for further studies examining whether sparing of this region might improve patients QoL. [ABSTRACT FROM AUTHOR] |
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