Current status and recent advances in reirradiation of glioblastoma
| العنوان: | Current status and recent advances in reirradiation of glioblastoma |
|---|---|
| المؤلفون: | Piera Navarria, Giuseppe Minniti, Filippo Alongi, Claus Belka, Maximilian Niyazi |
| المصدر: | Radiation Oncology, Vol 16, Iss 1, Pp 1-14 (2021) Radiation Oncology (London, England) |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | lcsh:Medical physics. Medical radiology. Nuclear medicine, medicine.medical_specialty, lcsh:R895-920, medicine.medical_treatment, Review, Radiosurgery, lcsh:RC254-282, Radionecrosis, Re-Irradiation, Hypofractionated radiotherapy, Stereotactic radiotherapy, 03 medical and health sciences, 0302 clinical medicine, Recurrent glioblastoma, Reirradiation, Stereotactic radiosurgery, Target delineation, medicine, Humans, Radiology, Nuclear Medicine and imaging, Radiation Injuries, Temozolomide, Brain Neoplasms, business.industry, Dose fractionation, Who grade, Prognosis, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Survival Analysis, Radiation therapy, Oncology, 030220 oncology & carcinogenesis, Concomitant, Dose Fractionation, Radiation, Radiology, Neoplasm Recurrence, Local, Glioblastoma, business, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | Despite aggressive management consisting of maximal safe surgical resection followed by external beam radiation therapy (60 Gy/30 fractions) with concomitant and adjuvant temozolomide, approximately 90% of WHO grade IV gliomas (glioblastomas, GBM) will recur locally within 2 years. For patients with recurrent GBM, no standard of care exists. Thanks to the continuous improvement in radiation science and technology, reirradiation has emerged as feasible approach for patients with brain tumors. Using stereotactic radiosurgery (SRS) or stereotactic radiotherapy (SRT), either hypofractionated or conventionally fractionated schedules, several studies have suggested survival benefits following reirradiation of patients with recurrent GBM; however, there are still questions to be answered about the efficacy and toxicity associated with a second course of radiation. We provide a clinical overview on current status and recent advances in reirradiation of GBM, addressing relevant clinical questions such as the appropriate patient selection and radiation technique, optimal dose fractionation, reirradiation tolerance of the brain and the risk of radiation necrosis. |
| تدمد: | 1748-717X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7374ae13f1fc0c8b59d4f91f8471baTest https://doi.org/10.1186/s13014-021-01767-9Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0a7374ae13f1fc0c8b59d4f91f8471ba |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1748717X |
|---|