PLEIOTROPIC EFFECTS OF PARATHYROIDECTOMY AND AGONIST CALCIUM-SENSITIVE RECEPTOR, CINACALCET
| العنوان: | PLEIOTROPIC EFFECTS OF PARATHYROIDECTOMY AND AGONIST CALCIUM-SENSITIVE RECEPTOR, CINACALCET |
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| المؤلفون: | L. Ya. Rozhinskaya, L. V. Egshatyan, M. Sh. Shamkhalova, N S Kuznetsov |
| المصدر: | Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 9, Iss 2, Pp 152-157 (2015) |
| بيانات النشر: | Stolichnaya Izdatelskaya Kompaniya, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Parathyroidectomy, medicine.medical_specialty, arterial hypertension, lcsh:Diseases of the circulatory (Cardiovascular) system, Cinacalcet, Anemia, medicine.medical_treatment, дислипидемия, RM1-950, цинакалцет, cinacalcet, parathyroidectomy, паратиреоидэктомия, secondary hyperparathyroidism, Internal medicine, Medicine, Diseases of the circulatory (Cardiovascular) system, Pharmacology (medical), Hyperparathyroidism, medicine.diagnostic_test, business.industry, dyslipidemia, lcsh:RM1-950, почечная анемия, артериальная гипертензия, medicine.disease, вторичный гиперпаратиреоз, Endocrinology, lcsh:Therapeutics. Pharmacology, lcsh:RC666-701, RC666-701, Secondary hyperparathyroidism, Hemodialysis, Therapeutics. Pharmacology, Cardiology and Cardiovascular Medicine, business, Lipid profile, Dyslipidemia, medicine.drug, renal anemia |
| الوصف: | Aim. To evaluate the effect of parathyroidectomy and cinacalcet on anemia, lipid profile and blood pressure (BP) in uremic hyperparathyroidism.Material and methods. Uremic patients (n=39) treated with hemodialysis and having secondary hyperparathyroidism were included into the study. Radical parathyroidectomy was performed in 21 patients, 18 patients were treated with cinacalcet. BP measurement, determination of blood levels of albumin, total calcium, phosphorus, total cholesterol (TC), low (LDL) and high density lipoproteins, triglycerides, intact parathyroid hormone, and hemoglobin were performed in all patients initially and during treatment. Doses of antihypertensive and erythropoiesis-stimulating agents were also assessed.Results. Calcium-phosphorus metabolism indices improved after 6 months of cinacalcet therapy and parathyroidectomy (pConclusion. The pleiotropic effects (reduction in BP and atherogenic lipids levels, as well as decrease in anemia resistant to the action of erythropoiesis-stimulating agents) were found after parathyroidectomy and cinacalcet therapy additionally to calcium-phosphorus metabolism improvement. |
| اللغة: | English |
| تدمد: | 2225-3653 1819-6446 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ad25731bd1f35df916429c06d19a68Test http://www.rpcardio.ru/jour/article/view/275Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....14ad25731bd1f35df916429c06d19a68 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22253653 18196446 |
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