التفاصيل البيبلوغرافية
| العنوان: |
Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer's disease. |
| المؤلفون: |
Airoldi, Cristina, Cardona, Francisco, Sironi, Erika, Colombo, Laura, Salmona, Mario, Cambianica, Ilaria, Ornaghi, Francesca, Sancini, Giulio, Nicotra, Francesco, La Ferla, Barbara |
| المصدر: |
Pure & Applied Chemistry; 2013, Vol. 85 Issue 9, p1813-1823, 11p, 1 Color Photograph, 5 Diagrams, 5 Graphs |
| مصطلحات موضوعية: |
FLUORESCENCE, AMYLOID, PEPTIDES, LIGANDS (Biochemistry), CHEMICAL derivatives, ALZHEIMER'S disease diagnosis, BLOOD-brain barrier |
| مستخلص: |
Aβ-peptide ligands based on a cis-glycofused benzopyran structure have been fluores cently labeled using coumarine derivatives. Among the synthesized compounds, two conserved their binding ability to β-amyloid peptides, as shown by NMR experiments. Moreover, exploiting its fluorescent property, it was demonstrated that one of such compounds was able to cross an in vitro model of blood--brain barrier (BBB) and to stain Aβ-deposits. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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