دورية أكاديمية
Synthesis, characterization and anti-diabetic therapeutic potential of novel aminophenol-derivatized nitrilotriacetic acid vanadyl complexes
| العنوان: | Synthesis, characterization and anti-diabetic therapeutic potential of novel aminophenol-derivatized nitrilotriacetic acid vanadyl complexes |
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| المؤلفون: | Wang, Na, Wang, Ziwei, Niu, Xia, Yang, Xiaoda |
| المساهمون: | Yang, XD (reprint author), Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Hlth Sci Ctr,State Key Labs Nat & Biomimet Drugs, Beijing 100191, Peoples R China., Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Hlth Sci Ctr,State Key Labs Nat & Biomimet Drugs, Beijing 100191, Peoples R China. |
| المصدر: | PubMed ; SCI |
| بيانات النشر: | JOURNAL OF INORGANIC BIOCHEMISTRY |
| سنة النشر: | 2015 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | Vanadium, Diabetes, Aminophenol, PPAR alpha, PPAR gamma, INSULIN-MIMETIC AGENT, OXIDATIVE STRESS, VANADIUM(IV) COMPLEXES, DIABETIC-RATS, PPAR-GAMMA, CHEMISTRY, ACTIVATION, CELLS, OXIDOVANADIUM(IV), MECHANISMS |
| الوصف: | In the present work, we synthesized three novel aminophenol-derivatized nitrilotriacetic acid vanadyl complexes (VOohpada, VOmhpada, VOphpada) using the strategy of rational incorporation of antioxidant groups in ligand in order to balance the side effects with the therapeutic properties. The complexes were characterized by IR, UV-VIS, ESI-MS and elemental analysis. The biological evaluations in vitro revealed that the position of the hydroxyl group of aminophenol moiety regulated the antioxidant activity of the complexes as well as the cytotoxicity on HK-2 cells. The vanadyl complex of p-hydroxyl aminophenol derivative (VOphpada) exhibited better antioxidant activity and lower cytotoxicity than other analogs. In type II diabetic db/db mice, VOphpada (0.1 mmol/kg/day) effectively reduced blood glucose level, improved glucose tolerance, and alleviated stresses induced by hyperglycemia and hyperlipidemia. VOphpada treatment significantly increased expression of PPARa and activated Akt, and inactivated JNK in muscle and adipose tissues. The insulin enhancement effects of VOphpada were observed more potent than BMOV. Moreover, VOphpada decreased the level of kidney injury molecule-1 marker (KIM-1), suggesting a potentially lower renal toxicity. In overall, the present results suggest VOphpada as a novel hypoglycemic agent with improved efficacy-over-toxicity index. (C) 2015 Elsevier Inc. All rights reserved. ; NNSFC [21271012] ; SCI(E) ; PubMed ; ARTICLE ; xyang@bjmu.edu.cn ; SI ; 104-113 ; 152 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0162-0134 1873-3344 |
| العلاقة: | JOURNAL OF INORGANIC BIOCHEMISTRY.2015,152,(,SI),104-113.; 1297117; http://hdl.handle.net/20.500.11897/418024Test; WOS:000367127800010 |
| DOI: | 10.1016/j.jinorgbio.2015.07.012 |
| الإتاحة: | https://doi.org/20.500.11897/418024Test https://doi.org/10.1016/j.jinorgbio.2015.07.012Test https://hdl.handle.net/20.500.11897/418024Test |
| رقم الانضمام: | edsbas.21FEE72F |
| قاعدة البيانات: | BASE |
| تدمد: | 01620134 18733344 |
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| DOI: | 10.1016/j.jinorgbio.2015.07.012 |