Clozapine metabolism rate as a possible index of drug-induced granulocytopenia
| العنوان: | Clozapine metabolism rate as a possible index of drug-induced granulocytopenia |
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| المؤلفون: | Renata Rudelli, E. Giuliani, R. Orlandi, A. Guerrini, S. Gianetti, Giordano Invernizzi, Massimo C. Mauri, Bravin S |
| المصدر: | Psychopharmacology. 137:341-344 |
| بيانات النشر: | Springer Science and Business Media LLC, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Adult, Male, Drug, medicine.medical_specialty, Leukocytosis, media_common.quotation_subject, Leukocyte Count, Pharmacokinetics, Risk Factors, Internal medicine, Humans, Medicine, Clozapine, media_common, Pharmacology, Leukopenia, business.industry, Plasma levels, Metabolism, Middle Aged, Endocrinology, Toxicity, Schizophrenia, Absolute neutrophil count, Female, medicine.symptom, business, Agranulocytosis, Antipsychotic Agents, medicine.drug |
| الوصف: | A possible relationship between haematological adverse reactions and clozapine (CLZ) metabolism rate was studied. Sixteen chronic schizophrenic outpatients (mean age 34.62 years +/- 7.56 SD) were treated with CLZ, 75-600 mg/daily for 9 weeks. CLZ and norclozapine (NCLZ) plasma levels were determined weekly, contemporarily with blood cell counts. CLZ plasma levels ranged from 25 to 1270 ng/ml (mean 266.27 ng/ml +/- 197.44 SD), while NCLZ plasma levels ranged from 25 to 1280 ng/ml (mean 169.0 ng/ml +/- 127.94 SD). NCLZ/CLZ ratio ranged from 0.13 to 1.72 (mean 0.72 +/- 0.28 SD). Leukocyte count ranged from 5.2 to 18.8 10(9)/l (mean 9.37 10(9)/l +/- 2.94 SD) and neutrophil count ranged from 1.8 to 13.4 10(9)/l (mean 5.73 +/- 2.57 SD). No correlation was found between CLZ dosage and NCLZ plasma levels. Both CLZ and NCLZ plasma levels correlated positively with neutrophil count (CLZ: P = 0.001, r = 0.26; NCLZ: P = 0.01, r = 0.20). The correlation between NCLZ/CLZ plasma level ratio and neutrophil count was significantly negative (P = 0.002, r = 0.25). These preliminary data suggest that the NCLZ/CLZ ratio, as an index of CLZ metabolism, might be a possible risk factor associated with CLZ treatment. |
| تدمد: | 1432-2072 0033-3158 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d231b05ab87ba6f7cc132554f9ea8afTest https://doi.org/10.1007/s002130050628Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....3d231b05ab87ba6f7cc132554f9ea8af |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14322072 00333158 |
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