دورية أكاديمية
Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats
| العنوان: | Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats |
|---|---|
| المؤلفون: | Richards, Jemma, Simms, Jeffrey, Steensland, Pia, Taha, Sharif, Borgland, Stephanie, Bonci, Antonello, Bartlett, Selena |
| المصدر: | Psychopharmacology |
| بيانات النشر: | Springer |
| سنة النشر: | 2008 |
| المجموعة: | Queensland University of Technology: QUT ePrints |
| مصطلحات موضوعية: | Ethanol, Hypocretin, Operant self administration, Orexin, Reinstatement, SB334867, Stress, Yohimbine |
| الوصف: | RATIONALE: Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and ethanol seeking. In the current study, we examined the role of orexin-1/hypocretin-1 receptors in operant self-administration of ethanol and sucrose and in yohimbine-induced reinstatement of ethanol and sucrose seeking. MATERIALS AND METHODS: Rats were trained to self-administer either 10% ethanol or 5% sucrose (30 min/day). The orexin-1 receptor antagonist SB334867 (0, 5, 10, 15, 20 mg/kg, i.p.) was administered 30 min before the operant self-administration sessions. After these experiments, the operant self-administration behaviors were extinguished in both the ethanol and sucrose-trained rats. Upon reaching extinction criteria, SB334867 (0, 5, 10 mg/kg, i.p.) was administered 30 min before yohimbine (0 or 2 mg/kg, i.p.). In a separate experiment, the effect of SB334867 (0, 15, or 20 mg/kg, i.p.) on general locomotor activity was determined using the open-field test. RESULTS: The orexin-1 receptor antagonist, SB334867 (10, 15 and 20 mg/kg) decreased operant self-administration of 10% ethanol but not 5% sucrose self-administration. Furthermore, SB334867 (5 and 10 mg/kg) significantly decreased yohimbine-induced reinstatement of both ethanol and sucrose seeking. SB334867 did not significantly affect locomotor activity measured using the open-field test. CONCLUSIONS: The results suggest that inhibition of OX-1/Hcrt-1 receptors modulates operant ethanol self-administration and also plays a significant role in yohimbine-induced reinstatement of both ethanol and sucrose seeking in rats. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | Richards, Jemma, Simms, Jeffrey, Steensland, Pia, Taha, Sharif, Borgland, Stephanie, Bonci, Antonello, & Bartlett, Selena (2008) Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats. Psychopharmacology, 199(1), pp. 109-117.; https://eprints.qut.edu.au/45210Test/; Faculty of Science and Technology |
| الإتاحة: | https://doi.org/10.1007/s00213-008-1136-5Test https://eprints.qut.edu.au/45210Test/ |
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| رقم الانضمام: | edsbas.9F444B96 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |