Ovarian Cancer: Tumor-Specific Urinary Micro-Peptides Profiling as Potential Biomarkers for Early Diagnosis
| العنوان: | Ovarian Cancer: Tumor-Specific Urinary Micro-Peptides Profiling as Potential Biomarkers for Early Diagnosis |
|---|---|
| المؤلفون: | Sulafa S Murgan, Eltahir A G Khalil, Faisal J Abd Elaziz, Abubakr M. Nasr, Mona E E Elfaki |
| المصدر: | Proteomes, Vol 8, Iss 32, p 32 (2020) Proteomes Volume 8 Issue 4 |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, medicine.medical_treatment, Urinary system, Clinical Biochemistry, lcsh:QR1-502, Urine, Biochemistry, Gastroenterology, Article, lcsh:Microbiology, Sudan, 03 medical and health sciences, 0302 clinical medicine, Structural Biology, Internal medicine, Medicine, Molecular Biology, chemistry.chemical_classification, Chemotherapy, biology, Edman degradation, business.industry, medicine.disease, ovarian cancer, 030104 developmental biology, chemistry, Catalase, 030220 oncology & carcinogenesis, Potential biomarkers, biology.protein, urinary micro-peptides, business, Ovarian cancer, Glycoprotein, early diagnosis |
| الوصف: | Ovarian cancer is the second major lethal gynecologic malignancy in developing countries. This study aimed to characterize urinary micro-peptides as potential diagnostic biomarkers for ovarian cancer. In a prospective, longitudinal and case-controlled study and following informed consent, urine and plasma samples were collected from 112 women with histologically-proven ovarian cancer and 200 apparently healthy age-matched volunteers. Urinary micro-peptides were detected and sequenced using SDS-PAGE and Edman degradation technique. Serum CA125 was detected in less than a quarter (23.2%, 26/112) of patients. One or more urinary micro-peptides were detected in about two thirds of the patients (62.5%, 70/112). A total of 40 patients had three bands (57.1%, 40/70), while two bands (15 and 35 kDa) were detected in 28.6% (20/70) of the patients. Isolated 45 kDa band was seen in 14.3% (10/70). No urinary micro-peptide was detected in the volunteers. The 15 and 35 kDa bands disappeared after 6 months of regular chemotherapy, while the 45 kDa band persisted in 2.9% (2/70) of the patients after treatment. The micro-peptides were identified as: Catalase (45 kDa), &alpha 1 Acid Glycoprotein (35 kDa) and Peroxiredoxin-2 (15 kDa). Urinary catalase, &alpha 1 Acid Glycoprotein and Peroxiredoxin-2 can be useful biomarkers for early detection and treatment response of ovarian cancer. |
| وصف الملف: | application/pdf |
| تدمد: | 2227-7382 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699defff42f1d3aa5095373307ea3542Test https://doi.org/10.3390/proteomes8040032Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....699defff42f1d3aa5095373307ea3542 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22277382 |
|---|